ArticleAmerican journal of blood research2013
Regulation of innate immunity by extracellular nucleotides.
Article in American journal of blood research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
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- The mitochondria as a potential therapeutic target in cerebral I/R injury.Frontiers in neuroscience · 2024Review
- Article
- Early approval of COVID-19 vaccines: Pros and cons.Human vaccines & immunotherapeutics · 2021Review
- Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity.International journal of biological macromolecules · 2021Article
- Moringa oleifera modulates cholinergic and purinergic enzymes activity in BV-2 microglial cells.Metabolic brain disease · 2021Article
- An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management.Pharmaceutics · 2020Review
- Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.Frontiers in medicine · 2020Review
- The Role of Heat Shock Protein 70 kDa in Asthma.Journal of asthma and allergy · 2020Review
- Extracellular adenosine triphosphate is associated with airflow limitation severity and symptoms burden in patients with chronic obstructive pulmonary disease.Scientific reports · 2019Article
- Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis.Inflammopharmacology · 2018Article
- Amino acids as modulators of the European seabass, Dicentrarchus labrax, innate immune response: an in vitro approach.Scientific reports · 2017Article
- Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells.Seminars in immunopathology · 2016Review
- Toll-like Receptors in the Vascular System: Sensing the Dangers Within.Pharmacological reviews · 2016Review
- Streptococcal 5'-Nucleotidase A (S5nA), a Novel Streptococcus pyogenes Virulence Factor That Facilitates Immune Evasion.The Journal of biological chemistry · 2015Article
- Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.Molecular autism · 2015Article
- Young capillary vessels rejuvenate aged pancreatic islets.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Putative roles of purinergic signaling in human immunodeficiency virus-1 infection.Biology direct · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular ATP (eATP) is the most abundant among extracellular nucleotides and is commonly considered as a classical danger signal, which stimulates immune responses in the presence of tissue injury. In fact, increased nucleotide concentration in the extracellular space is generally closely associated with tissue stress or damage. However non-lytic nucleotide release may also occur in many cell types under a variety of conditions. Extracellular nucleotides are sensed by a class of plasma membrane receptors called P2 purinergic receptors (P2Rs). P2 receptors are expressed by all immunological cells and their activation elicits different responses. Extracellular ATP can act as an initiator or terminator of immune responses being able to induce different effects on immune cells depending on the pattern of P2 receptors engaged, the duration of the stimulus and its concentration in the extracellular milieu. Millimolar (high) concentrations of extracellular ATP, induce predominantly proinflammatory effects, while micromolar (low) doses exert mainly tolerogenic/immunosuppressive action. Moreover small, but significant differences in the pattern of P2 receptor expression in mice and humans confer diverse capacities of ATP in regulating the immune response.
Indexed as
Identifiers
23358447PMC3555188W104784717What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.