Evidence map›Paper›PMID 23358157›Full record

ArticleMolecular psychiatry2014

DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12.

M Trzaskowski, J Yang, P M Visscher, R Plomin

Abstract readTwin Study
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. A statistical genetic investigation of psychiatric resilience.European journal of psychotraumatology · 2023
    Article
  7. Article
  8. Review
  9. Review
  10. Psychotic experiences and future school performance in childhood: a population-based cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Sociogenomics in the 21Sociology compass · 2018
    Article
  17. Heritability and genome-wide associations studies of cerebral blood flow in the general population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M TrzaskowskiKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Denmark Hill, London, UK.
J YangUniversity of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
P M Visscher1] University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia [2] Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
R PlominKing's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Denmark Hill, London, UK.

Funding

Genetics, School environments and cognitive developmentR01HD044454 · NICHD · KING'S COLLEGE LONDON · PI PLOMIN, ROBERT · 2005 to 2014
$3.4M
GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIESR01HD046167 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI PETRILL, STEPHEN A · 2003 to 2005
$1.6M
European Research Council 295366Medical Research Council G0500079Medical Research Council G0500079(73692)Medical Research Council G0901245Medical Research Council G19/2Medical Research Council G19/2(78332)NICHD NIH HHS HD044454NICHD NIH HHS HD046167NICHD NIH HHS R01 HD044454NICHD NIH HHS R01 HD046167Wellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

Two genetic findings from twin research have far-reaching implications for understanding individual differences in the development of brain function as indexed by general cognitive ability (g, aka intelligence): (1) The same genes affect g throughout development, even though (2) heritability increases. It is now possible to test these hypotheses using DNA alone. From 1.7 million DNA markers and g scores at ages 7 and 12 on 2875 children, the DNA genetic correlation from age 7 to 12 was 0.73, highly similar to the genetic correlation of 0.75 estimated from 6702 pairs of twins from the same sample. DNA-estimated heritabilities increased from 0.26 at age 7 to 0.45 at age 12; twin-estimated heritabilities also increased from 0.35 to 0.48. These DNA results confirm the results of twin studies indicating strong genetic stability but increasing heritability for g, despite mean changes in brain structure and function from childhood to adolescence.

Indexed as

Child DevelopmentQuantitative Trait, HeritableAgingChildFemaleGenetic MarkersHumansIntelligenceIntelligence TestsMaleTwinsGenetic Markers

Identifiers

PMID23358157
PMCPMC3932402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.