Evidence map›Paper›PMID 23358156›Full record

SynthesisMolecular psychiatry2014

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.

B Benyamin, Bst Pourcain, O S Davis, G Davies, N K Hansell, M-J A Brion, R M Kirkpatrick, R A M Cents, S Franić, M B Miller and 34 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 19 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 19 syntheses or guidelines pooled it, 278 citations in OpenAlex.

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  10. The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
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  13. Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015
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  17. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Proceedings of the National Academy of Sciences of the United States of America · 2014
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 16 institutions in 5 countries.

B Benyamin1] The University of Queensland, Queensland Brain Institute, St Lucia, Queensland, Australia [2] Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Bst PourcainMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
O S DavisKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
G DaviesDepartment of Psychology, University of Edinburgh, Edinburgh, Scotland, UK.
N K HansellQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
M-J A Brion1] Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK [2] School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.
R M KirkpatrickDepartment of Psychology, University of Minnesota, St Paul, MN, USA.
R A M Cents1] The Generation R Study Group, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands [2] Department of Child and Adolescent Psychiatry, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands.
S FranićNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
M B MillerDepartment of Psychology, University of Minnesota, St Paul, MN, USA.
C M A HaworthKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
E MeaburnDepartment of Psychology, Birkbeck University of London, London, UK.
T S PriceKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
D M EvansMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
N TimpsonMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
J KempMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
S RingMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
W McArdleMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
S E MedlandQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
J YangThe University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
S E Harris1] Molecular Medicine Centre, Institute for Genetics and Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
D C Liewald1] Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
P ScheetNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
X XiaoDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J J HudziakDepartment of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA.
E J C de GeusNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Wellcome Trust Case Control Consortium 2 (WTCCC2)
V W V Jaddoe1] The Generation R Study Group, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands [2] Department of Epidemiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands [3] Department of Pediatrics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
J M Starr1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK [2] Alzheimer Scotland Dementia Research Centre, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK.
F C VerhulstDepartment of Child and Adolescent Psychiatry, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands.
C PennellSchool of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.
H Tiemeier1] Department of Child and Adolescent Psychiatry, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands [2] Department of Epidemiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands [3] Department of Psychiatry, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands.
W G IaconoDepartment of Psychology, University of Minnesota, St Paul, MN, USA.
L J Palmer1] Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, University of Toronto, Toronto, Ontario, Canada [2] Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada.
G W MontgomeryQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
N G MartinQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
D I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
D Posthuma1] Department of Child and Adolescent Psychiatry, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, The Netherlands [2] Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam (NCA), VU University Amsterdam and VU Medical Centre, Amsterdam, The Netherlands [3] Department of Clinical Genetics, Section Medical Genomics, VU Medical Centre, Amsterdam, The Netherlands.
M McGue1] Department of Psychology, University of Minnesota, St Paul, MN, USA [2] Department of Epidemiology, University of Southern Denmark, Odense, Denmark.
M J WrightQueensland Institute of Medical Research, Brisbane, Queensland, Australia.
G Davey SmithMedical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK.
I J Deary1] Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
R PlominKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK.
P M Visscher1] The University of Queensland, Queensland Brain Institute, St Lucia, Queensland, Australia [2] Queensland Institute of Medical Research, Brisbane, Queensland, Australia [3] The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia [4] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Medical Research Council · GBQIMR Berghofer Medical Research Institute · AUUniversity of Edinburgh · GBKing's College London · GBUniversity of Minnesota · USVrije Universiteit Amsterdam · NLErasmus University Rotterdam · NLErasmus MC · NLUniversity of Bristol · GBBirkbeck, University of London · GBLunenfeld-Tanenbaum Research Institute · CAPrincess Alexandra Hospital · AUThe University of Queensland · AUThe University of Texas MD Anderson Cancer Center · USThe University of Western Australia · AUUniversity of Vermont · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
TWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0M
BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B · 2001 to 2013
$7.8M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
Twin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4M
A Longitudinal Study of Adopted Youth and Their FamiliesR01MH066140 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 2003 to 2013
$5.8M
Biotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/505Chief Scientist Office ETM/55Medical Research Council G0500079Medical Research Council G0700704Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/1Medical Research Council MR/K026992/1NCI NIH HHS CA55075NCI NIH HHS CA87969NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01HG004399NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01HG004424NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01HL59367NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011886NIAAA NIH HHS R37 AA009367NICHD NIH HHS R01 HD050735NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA013240NIDA NIH HHS R25 DA026119NIDA NIH HHS R37 DA005147NIDA NIH HHS U01 DA024417NIDDK NIH HHS DK58845NIDDK NIH HHS R01 DK058845NIMH NIH HHS R01 MH066140Wellcome Trust 092731
6 · The paper itself

Abstract

Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational attainment, income, health and lifespan. Results from twin, family and adoption studies are consistent with general intelligence being highly heritable and genetically stable throughout the life course. No robustly associated genetic loci or variants for childhood intelligence have been reported. Here, we report the first genome-wide association study (GWAS) on childhood intelligence (age range 6-18 years) from 17,989 individuals in six discovery and three replication samples. Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts (P=3.9 × 10(-15), 0.014 and 0.028). FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly associated with childhood intelligence (P=0.003). Polygenic prediction analyses resulted in a significant correlation between predictor and outcome in all replication cohorts. The proportion of childhood intelligence explained by the predictor reached 1.2% (P=6 × 10(-5)), 3.5% (P=10(-3)) and 0.5% (P=6 × 10(-5)) in three independent validation cohorts. Given the sample sizes, these genetic prediction results are consistent with expectations if the genetic architecture of childhood intelligence is like that of body mass index or height. Our study provides molecular support for the heritability and polygenic nature of childhood intelligence. Larger sample sizes will be required to detect individual variants with genome-wide significance.

Indexed as

Multifactorial InheritanceAdolescentCarrier ProteinsChildCohort StudiesFemaleGenome-Wide Association StudyGenotyping TechniquesHumansIntelligenceIntelligence TestsMalePhenotypePolymorphism, Single NucleotideQuantitative Trait, HeritableSoftwareCarrier ProteinsFNBP1L protein, human

Identifiers

PMID23358156
PMCPMC3935975
OpenAlexW2170458546

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.