ArticleMolecular psychiatry2014
Sharing pain and relief: neural correlates of physicians during treatment of patients.
Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of brain mechanisms of placebo analgesia: consistent findings and unanswered questions.Handbook of experimental pharmacology · 2014Pooled it
- Placebo improves pleasure and pain through opposite modulation of sensory processing.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Interpersonal Coordination Deficits in Joint Action in Pre-school Children With Autism Spectrum Disorder: Evidence From fNIRS Hyper-Scanning and Machine Learning.Journal of autism and developmental disorders · 2026Article
- Not on the same wavelength? How autistic traits influence cooperation: evidence from fNIRS hyperscanning.Frontiers in psychiatry · 2024Article
- Brain-to-brain mechanisms underlying pain empathy and social modulation of pain in the patient-clinician interaction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Why should I switch on my camera? Developing the cognitive skills of compassionate communications for online group/teamwork management.Frontiers in psychology · 2023Article
- Pain control based on oscillatory brain activity using transcranial alternating current stimulation: An integrative review.Frontiers in human neuroscience · 2023Review
- Limited prognostic value of pain duration in non-specific neck pain patients seeking chiropractic care.European journal of pain (London, England) · 2022Article
- The Impact of Scripted Self-Hypnotic Relaxation on the Periprocedural Experience and Anesthesiologist Sedation Use in the Pediatric Cardiac Catheterization Suite: A Prospective Randomized Controlled Trial.Journal of pain research · 2022Article
- Self-Processing and Self-Face Reaction Time Latencies: A Review.Brain sciences · 2021Review
- What Do Placebo and Nocebo Effects Have to Do With Health Equity? The Hidden Toll of Nocebo Effects on Racial and Ethnic Minority Patients in Clinical Care.Frontiers in psychology · 2021Review
- How Negative Is Negative Information.Frontiers in neuroscience · 2021Article
- Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction.Science advances · 2020Article
- Patient-Clinician Brain Response During Clinical Encounter and Pain Treatment.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- Article
- Reward and empathy in the treating clinician: the neural correlates of successful doctor-patient interactions.Translational psychiatry · 2020Article
- Socially transmitted placebo effects.Nature human behaviour · 2019Article
- Sensory neuropathy and nociception in rodent models of Parkinson's disease.Disease models & mechanisms · 2019Review
- Expertise Modulates Students' Perception of Pain From a Self-Perspective: Quasi-Experimental Study.Journal of medical Internet research · 2019Article
- The Clinical Implications of Nocebo Effects for Biosimilar Therapy.Frontiers in pharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Patient-physician interactions significantly contribute to placebo effects and clinical outcomes. While the neural correlates of placebo responses have been studied in patients, the neurobiology of the clinician during treatment is unknown. This study investigated physicians' brain activations during patient-physician interaction while the patient was experiencing pain, including a 'treatment', 'no-treatment' and 'control' condition. Here, we demonstrate that physicians activated brain regions previously implicated in expectancy for pain-relief and increased attention during treatment of patients, including the right ventrolateral and dorsolateral prefrontal cortices. The physician's ability to take the patients' perspective correlated with increased brain activations in the rostral anterior cingulate cortex, a region that has been associated with processing of reward and subjective value. We suggest that physician treatment involves neural representations of treatment expectation, reward processing and empathy, paired with increased activation in attention-related structures. Our findings further the understanding of the neural representations associated with reciprocal interactions between clinicians and patients; a hallmark for successful treatment outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.