ReviewFrontiers in neuroendocrinology2013
Organizational actions of metabolic hormones.
Review in Frontiers in neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Low Levels of Serum Ghrelin and Nesfatin-1 Are Associated With Anxiety Disorders in Children.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2025Article
- Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits.Molecular metabolism · 2024Article
- Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus.Molecular brain · 2020Article
- Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.Molecular metabolism · 2020Article
- Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice.Nutrients · 2020Article
- Review
- Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.Cell metabolism · 2019Article
- Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort.Autism research : official journal of the International Society for Autism Research · 2018Article
- Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.Toxicological sciences : an official journal of the Society of Toxicology · 2018Review
- Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions ofFrontiers in endocrinology · 2017Article
- Neonatal overfeeding disrupts pituitary ghrelin signalling in female rats long-term; Implications for the stress response.PloS one · 2017Article
- Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia.Molecular metabolism · 2016Article
- Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens.Biology of sex differences · 2016Article
- Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats.Biology of sex differences · 2016Article
- Quality of life and hormones after sex reassignment surgery.Journal of endocrinological investigation · 2015Article
- Developmental specification of metabolic circuitry.Frontiers in neuroendocrinology · 2015Review
- Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus.Molecular metabolism · 2015Article
- Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling.Diabetes · 2015Article
- Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development.Frontiers in endocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
Brain development is a complex and dynamic process, and many environmental factors have been found to influence the normal development of neural pathways. Cumulative evidence suggests that metabolic hormones that regulate the hypothalamic circuits that control energy homeostasis function in much the same way that sex steroids act on sexually dimorphic circuits. For example, although the effects of the adipocyte-derived hormone leptin were originally thought to be limited to the neural control of energy homeostasis in adult animals, it is now becoming increasingly clear that leptin can also determine patterns of neurogenesis, axon growth, and synaptic plasticity in the developing hypothalamus. More recent studies have also extended the role of the metabolic hormones ghrelin and insulin in various aspects of brain development. Examining how metabolic hormones control hypothalamic development will help our understanding of the developmental origin of adult metabolic diseases and, hopefully, improve our ability to predict adverse outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.