Trial reportJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2013
Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis.
Trial report in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients.Clinical nutrition (Edinburgh, Scotland) · 2019Trial
- Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults.Metabolism: clinical and experimental · 2017Trial
- High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2015Trial
- Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults.American journal of physiology. Endocrinology and metabolism · 2015Trial
- Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion.Clinical nutrition (Edinburgh, Scotland) · 2014Trial
- Validation of dietary whey protein substrate challenge absorption test as an indicator of proteolysis.PloS one · 2025Article
- Consideration of the role of protein quality in determining dietary protein recommendations.Frontiers in nutrition · 2024Review
- Purinosomes involved in the regulation of tumor metabolism: current progress and potential application targets.Frontiers in oncology · 2024Review
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance.Journal of the International Society of Sports Nutrition · 2023Article
- Nutritional Status and Body Composition in Patients Suffering From Chronic Respiratory Diseases and Its Correlation With Pulmonary Rehabilitation.Frontiers in rehabilitation sciences · 2021Review
- Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer.Clinical nutrition (Edinburgh, Scotland) · 2018Article
- Update on maximal anabolic response to dietary protein.Clinical nutrition (Edinburgh, Scotland) · 2018Review
- Personalizing protein nourishment.Critical reviews in food science and nutrition · 2017Review
- Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig.American journal of physiology. Endocrinology and metabolism · 2017Article
- Presence of early stage cancer does not impair the early protein metabolic response to major surgery.Journal of cachexia, sarcopenia and muscle · 2017Article
- The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.Metabolic brain disease · 2017Article
- Review
- New stable isotope method to measure protein digestibility and response to pancreatic enzyme intake in cystic fibrosis.Clinical nutrition (Edinburgh, Scotland) · 2014Article
- Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis.Current opinion in clinical nutrition and metabolic care · 2014Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCurrent nutritional approaches have been partially successful in Cystic Fibrosis (CF). Essential amino acids mixtures with high Leucine levels (EAA) have anabolic properties in catabolic conditions, however data in CF are lacking.
methodsOn two days according a randomized crossover design, 15 pediatric CF patients ingested 6.7 g EAA versus mixture of total amino acids as present in whey. Whole body protein and Arginine metabolism (as EAA lack Arginine) were assessed by stable isotope methodology.
resultsProtein synthesis (P<0.05) but not protein breakdown was higher after EAA and 70% higher values for net anabolism (P<0.001)were found both in patients with and without nutritional failure. Arginine turnover was lower (P<0.001) and de novo Arginine synthesis tended lower (P=0.09) after EAA. Nitric oxide synthesis was not different.
conclusionsCF patients are highly responsive to EAA intake independent of their nutritional status. Addition of Arginine to the EAA mixture may be warranted in CF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.