Evidence map›Paper›PMID 23357442›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2013

Does childhood attention-deficit/hyperactivity disorder predict risk-taking and medical illnesses in adulthood?

Maria A Ramos Olazagasti, Rachel G Klein, Salvatore Mannuzza, Erica Roizen Belsky, Jesse A Hutchison, Erin C Lashua-Shriftman, F Xavier Castellanos

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 95 citations in OpenAlex.

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  6. Does attention-deficit/hyperactivity disorder increase the risk of minor blunt head trauma in children?Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc · 2022
    Observational
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  15. Accident patterns in trauma surgery patients with and without self-reported ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2019
    Article
  16. Article
  17. Review
  18. Article
  19. Risk of mild head injury in preschool children: relationship to attention deficit hyperactivity disorder symptoms.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Maria A Ramos OlazagastiNew York University Medical Center, New York, NY 10016, USA.
Rachel G Klein
Salvatore Mannuzza
Erica Roizen Belsky
Jesse A Hutchison
Erin C Lashua-Shriftman
F Xavier Castellanos
New York University · USAmerican University · USColumbia University · USColumbia University Irving Medical Center · US

Funding

Research Training in Translational Developmental NeuroscienceT32MH067763 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2003 to 2013
$2.9M
CHILDHOOD STIMULANT EXPOSURE IMPACT ON LATER DRUG ABUSER01DA016979 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2003 to 2008
$2.8M
PROSPECTIVE LONGITUDINAL STUDY OF HYPERACTIVE CHILDREN (R01MH018579 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI KLEIN, RACHEL G · 1985 to 1994
–
NIDA NIH HHS DA-16979NIDA NIH HHS R01 DA016979NIMH NIH HHS MH-18579NIMH NIH HHS T32 MH067763NIMH NIH HHS T32MH-067763
6 · The paper itself

Abstract

objectiveTo test whether children with attention-deficit/hyperactivity disorder (ADHD), free of conduct disorder (CD) in childhood (mean = 8 years), have elevated risk-taking, accidents, and medical illnesses in adulthood (mean = 41 years); whether development of CD influences risk-taking during adulthood; and whether exposure to psychostimulants in childhood predicts cardiovascular disease. We hypothesized positive relationships between childhood ADHD and risky driving (in the past 5 years), risky sex (in the past year), and between risk-taking and medical conditions in adulthood; and that development of CD/antisocial personality (APD) would account for the link between ADHD and risk-taking. We report causes of death.

methodProspective 33-year follow-up of 135 boys of white ethnicity with ADHD in childhood and without CD (probands), and 136 matched male comparison subjects without ADHD (comparison subjects; mean = 41 years), blindly interviewed by clinicians.

resultsIn adulthood, probands had relatively more risky driving, sexually transmitted disease, head injury, and emergency department admissions (p< .05-.01). Groups did not differ on other medical outcomes. Lifetime risk-taking was associated with negative health outcomes (p = .01-.001). Development of CD/APD accounted for the relationship between ADHD and risk-taking. Probands without CD/APD did not differ from comparison subjects in lifetime risky behaviors. Psychostimulant treatment did not predict cardiac illness (p = .55). Probands had more deaths not related to specific medical conditions (p = .01).

conclusionsOverall, among children with ADHD, it is those who develop CD/APD who have elevated risky behaviors as adults. Over their lifetime, those who did not develop CD/APD did not differ from comparison subjects in risk-taking behaviors. Findings also provide support for long-term safety of early psychostimulant treatment.

Indexed as

Antisocial Personality DisorderAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsRisk-TakingAccidents, TrafficAdmitting Department, HospitalAdultCardiovascular DiseasesChildDiagnostic and Statistical Manual of Mental DisordersFollow-Up StudiesHumansMaleNew York CityOutcome Assessment, Health CarePersonality DevelopmentCentral Nervous System Stimulants

Identifiers

PMID23357442
PMCPMC3662801
OpenAlexW2105323867

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.