Evidence map›Paper›PMID 23357439›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2013

Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy.

David J Miklowitz, Christopher D Schneck, Manpreet K Singh, Dawn O Taylor, Elizabeth L George, Victoria E Cosgrove, Meghan E Howe, L Miriam Dickinson, Judy Garber, Kiki D Chang

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 79 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00943085 nacompletednot on this map

Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2011Enrolled52ConditionsBipolar DisorderArmsFamily-focused therapy, Brief educational treatment
NCT02097563 phase2completednot on this mapstarted 2014, after this paper: background citation

Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders

TypeinterventionalSponsorUniversity of California, Los AngelesRan2014 to 2019Enrolled133ConditionsMood Disorders, Psychotic DisordersArmsHigh Intensity Training, Low Intensity Training
NCT02355366 naterminatednot on this mapstarted 2015, after this paper: background citation

Family Focused Therapy (FFT) for Adolescents at Familial Risk for Bipolar

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2015 to 2018Enrolled2ConditionsBipolar DisorderArmsFamily-Focused Therapy, Brief Educational Treatment
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  11. Effects of an adolescent depression prevention program on maternal criticisms and positive remarks.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2020
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  15. Family communication with teens at clinical high-risk for psychosis or bipolar disorder.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2018
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  16. A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2017
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

David J MiklowitzUniversity of California-Los Angeles School of Medicine, Los Angeles, CA 90024, USA. dmiklowitz@mednet.ucla.edu
Christopher D Schneck
Manpreet K Singh
Dawn O Taylor
Elizabeth L George
Victoria E Cosgrove
Meghan E Howe
L Miriam Dickinson
Judy Garber
Kiki D Chang

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Genetic and Neurobiologic Risk Factors for Bipolar Disorder DevelopmentR01MH077047 · NIMH · STANFORD UNIVERSITY · PI CHANG, KIKI D · 2007 to 2011
$2.9M
Family-Focused Treatment for Bipolar AdolescentsR01MH073871 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2006 to 2010
$1.7M
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS MH073871NIMH NIH HHS MH077047NIMH NIH HHS MH077856NIMH NIH HHS MH093676NIMH NIH HHS R01 MH073871NIMH NIH HHS R01 MH077047NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R34 MH077856
6 · The paper itself

Abstract

objectiveDepression and brief periods of (hypo)mania are linked to an increased risk of progression to bipolar I or II disorder (BD) in children of bipolar parents. This randomized trial examined the effects of a 4-month family-focused therapy (FFT) program on the 1-year course of mood symptoms in youth at high familial risk for BD, and explored its comparative benefits among youth in families with high versus low expressed emotion (EE).

methodParticipants were 40 youth (mean 12.3±2.8 years, range 9-17) with BD not otherwise specified, major depressive disorder, or cyclothymic disorder who had a first-degree relative with BD I or II and active mood symptoms (Young Mania Rating Scale [YMRS]>11 or Child Depression Rating Scale>29). Participants were randomly allocated to FFT-High Risk version (FFT-HR; 12 sessions of psychoeducation and training in communication and problem-solving skills) or an education control (EC; 1-2 family sessions).

resultsYouth in FFT-HR had more rapid recovery from their initial mood symptoms (hazard ratio = 2.69, p = .047), more weeks in remission, and a more favorable trajectory of YMRS scores over 1 year than youth in EC. The magnitude of treatment effect was greater among youth in high-EE (versus low-EE) families.

conclusionsFFT-HR may hasten and help sustain recovery from mood symptoms among youth at high risk for BD. Longer follow-up will be necessary to determine whether early family intervention has downstream effects that contribute to the delay or prevention of full manic episodes in vulnerable youth.

Indexed as

Bipolar DisorderAdolescentAffectBehavioral SymptomsChildEarly Medical InterventionExpressed EmotionFamily HealthFamily TherapyFemaleHumansMalePsychiatric Status Rating ScalesRisk FactorsTreatment Outcome

Identifiers

PMID23357439
PMCPMC3558946

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.