ArticleBiochemical and biophysical research communications2013
Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations.
Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.Signal transduction and targeted therapy · 2025Review
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Comparative susceptibility of children and adults to neurological effects of inhaled manganese: A review of the published literature.Environmental research · 2023Review
- Tuneable manganese oxide nanoparticle based theranostic agents for potential diagnosis and drug delivery.Nanoscale advances · 2021Article
- Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model.Molecules (Basel, Switzerland) · 2021Article
- The impact of manganese on neurotransmitter systems.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020Review
- Ferroportin disease mutations influence manganese accumulation and cytotoxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study.Neurotoxicology · 2018Article
- Manganese and Developmental Neurotoxicity.Advances in neurobiology · 2017Review
- Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.Advances in neurobiology · 2017Review
- Manganese Toxicity Upon Overexposure: a Decade in Review.Current environmental health reports · 2015Review
- Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson's Disease: Environmental and Genetic Evidence.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Ferroportin deficiency impairs manganese metabolism in flatiron mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Manganese-induced Neurotoxicity: FromToxicology research · 2015Article
- Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone.Toxicology letters · 2014Article
- Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders.Frontiers in molecular neuroscience · 2014Review
- High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Bone research · 2014Article
- Altered expression of ZnT10 in Alzheimer's disease brain.PloS one · 2013Article
- Manganese in health and disease.Metal ions in life sciences · 2013Review
- Diagnosis of manganism and manganese neurotoxicity: A workshop report.Medicine internationalArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Although manganese (Mn) is required for normal cellular function, overexposure to this metal may cause an extrapyramidal syndrome resembling Parkinson's disease (PD). Notably, high whole-blood Mn levels have been reported in patients with idiopathic PD. Because Mn is both essential at low dose and toxic at higher dose; its transport and homeostasis are tightly regulated. Previously, the only protein known to be operant in cellular Mn export was the iron-regulating transporter, ferroportin (Fpn). The causal role for Mn in PD has yet to be fully understood, but evidence of a familial predisposition to PD associated with Mn toxicity is mounting. A recently discovered mutation in SLC30A10 identified its gene product as putatively involved in Mn efflux. Patients with the SLC30A10 mutation display Parkinsonian-like gate disturbances and hypermanganesemia. This review will address Mn transport proteins, the newly discovered SLC30A10 mutations and their implications to Parkinsonism and Mn regulation.
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Registered trials
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