ArticleUltrasonics sonochemistry2013
The impact of bubbles on measurement of drug release from echogenic liposomes.
Article in Ultrasonics sonochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Optimized TELIP, an Echogenic Liposomal Nano-Carrier Loaded with Alteplase for Preclinical Studies.Pharmaceutics · 2026Article
- Sonopharmacology: controlling pharmacotherapy and diagnosis by ultrasound-induced polymer mechanochemistry.Chemical science · 2022Review
- The Investigation of Gas Distribution Asymmetry Effect on Coriolis Flowmeter Accuracy at Multiphase Metering.Sensors (Basel, Switzerland) · 2022Article
- Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model.Scientific reports · 2021Article
- A thrombolytic therapy using diagnostic ultrasound combined with RGDS-targeted microbubbles and urokinase in a rabbit model.Scientific reports · 2020Article
- Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.Journal of thrombosis and thrombolysis · 2015Article
- Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.Ultrasound in medicine & biology · 2015Article
- Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging.International journal of nanomedicine · 2015Article
- pH-triggered echogenicity and contents release from liposomes.Molecular pharmaceutics · 2014Article
- Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery.Computational mechanics · 2014Article
- Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.Ultrasound in medicine & biology · 2014Article
- Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound.The Journal of the Acoustical Society of America · 2014Article
- Relationship between cavitation and loss of echogenicity from ultrasound contrast agents.Physics in medicine and biology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Echogenic liposomes (ELIP) encapsulate gas bubbles and drugs within lipid vesicles, but the mechanisms of ultrasound-mediated drug release from ELIP are not well understood. The effect of cavitation activity on drug release from ELIP was investigated in flowing solutions using two fluorescent molecules: a lipophilic drug (rosiglitazone) and a hydrophilic drug substitute (calcein). ELIP samples were exposed to pulsed Doppler ultrasound from a clinical diagnostic ultrasound scanner at pressures above and below the inertial and stable cavitation thresholds. Control samples were exposed to a surfactant, Triton X-100 (positive control), or to flow alone (negative control). Fluorescence techniques were used to detect release. Encapsulated microbubbles reduced the measured fluorescence intensity and this effect should be considered when assessing drug release from ELIP. The origin of this effect is not specific to ELIP. Release of rosiglitazone or calcein compared to the negative control was only observed with detergent treatment, but not with ultrasound exposure, despite the presence of stable and inertial cavitation activity. Release of rosiglitazone or calcein from ELIP exposed to diagnostic ultrasound was not observed, even in the presence of cavitation activity. Ultrasound-mediated drug delivery strategies with ELIP will thus rely on passage of the drug-loaded liposomes to target tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.