ArticleMathematical biosciences2013
Virus dynamics in the presence of synaptic transmission.
Article in Mathematical biosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dynamical modeling and data analysis of HIV infection with infection-age, CTLs immune response and delayed antibody immune response.Journal of mathematical biology · 2025Article
- A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV.PLoS computational biology · 2021Article
- Dynamics of a new HIV model with the activation status of infected cells.Journal of mathematical biology · 2021Article
- Modeling the role of macrophages in HIV persistence during antiretroviral therapy.Journal of mathematical biology · 2020Article
- Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV.Journal of the Royal Society, Interface · 2020Article
- Global Properties of Latent Virus Dynamics Models with Immune Impairment and Two Routes of Infection.High-throughput · 2019Article
- Synaptic transmission may provide an evolutionary benefit to HIV through modulation of latency.Journal of theoretical biology · 2018Article
- Accounting for Space—Quantification of Cell-To-Cell Transmission Kinetics Using Virus Dynamics Models.Viruses · 2018Article
- The role of spatial heterogeneity in the evolution of local and global infections of viruses.PLoS computational biology · 2018Article
- Fighting Cancer with Mathematics and Viruses.Viruses · 2017Review
- Modeling Viral Spread.Annual review of virology · 2016Review
- Article
- Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection.PLoS computational biology · 2015Article
- Contribution of HIV-1 genomes that do not integrate to the basic reproductive ratio of the virus.Journal of theoretical biology · 2015Article
- Commentary: With a little help from my enteric microbial friends.Frontiers in microbiology · 2015Article
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2 authors.
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Abstract
Traditionally, virus dynamics models consider populations of infected and target cells, and a population of free virus that can infect susceptible cells. In recent years, however, it has become. clear that direct cell-to-cell transmission can also play an important role for the in vivo spread of viruses, especially retroviruses such as human T lymphotropic virus-1 (HTLV-1) and Human immunodeficiency virus (HIV). Such cell-to-cell transmission is thought to occur through the formation of virological synapses that are formed between an infected source cell and a susceptible target cell. Here we formulate and analyze a class of virus dynamics models that include such cell-cell synaptic transmission. We explore different "strategies" of the virus defined by the number of viruses passed per synapse, and determine how the choice of strategy influences the basic reproductive ratio, R0, of the virus and thus its ability to establish a persistent infection. We show that depending on specific assumptions about the viral kinetics, strategies with low or intermediate numbers of viruses transferred may correspond to the highest values of R0. We also explore the evolutionary competition of viruses of different strains, which differ by their synaptic strategy, and show that viruses characterized by synaptic strategies with the highest R0 win the evolutionary competition and exclude other, inferior, strains.
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