ArticleJournal of psychiatric research2013
The involvement of 5-lipoxygenase activating protein in anxiety-like behavior.
Article in Journal of psychiatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Neuropsychiatric events associated with montelukast in patients with asthma: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- The identification and validation of histone acetylation-related biomarkers in depression disorder based on bioinformatics and machine learning approaches.Frontiers in neuroscience · 2025Article
- Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses.Neurotoxicity research · 2024Article
- Paradoxical Effect of LTBFrontiers in behavioral neuroscience · 2019Article
- Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice.BioMed research international · 2018Article
- Similar adverse events from two disparate agents implicate lipid inflammatory mediators for a role in anxiety states.Oxford medical case reports · 2017Article
- Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.Molecular psychiatry · 2016Article
- Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.Neurobiology of aging · 2014Article
- Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.Neurobiology of aging · 2014Article
- Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice.PloS one · 2014Article
- Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice.Aging cell · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The 5-lipoxygenase is an enzyme widely expressed in the central nervous system, where its activity is dependent on the presence the 5-lipoxygenase activating protein (FLAP) for the formation of leukotrienes, potent bioactive lipid mediators. Emerging evidence has shown that the FLAP/leukotriene pathway may play a role in neuropsychiatric disease contexts. In this study we investigated whether genetic deficiency of FLAP (FLAPKO) modulated some behavioral aspects in mice, and if this effect was age-dependent. While we observed that FLAPKO mice at 3 and 6 months of age did not different from wild type animals in the elevated plus maze, at 12 months of age they manifested a significant increase in anxiety-like behavior. By contrast, we observed no differences between FLAPKO mice and their controls at any of the three ages considered when they were tested for working memory in the Y maze paradigm. Additionally, while we found that cFOS protein and message levels were reduced in the brains of animals lacking FLAP, no changes for other transcription factors were detected. Taken together our findings suggest a novel role for FLAP in the pathogenesis of anxiety-like behavior. Future studies of FLAP neurobiology may be attractive for development of anxiolytic therapeutics.
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