ArticleBMC evolutionary biology2013
The evolution of antibiotic susceptibility and resistance during the formation of Escherichia coli biofilms in the absence of antibiotics.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition.PLoS pathogens · 2026Article
- Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models.NPJ biofilms and microbiomes · 2026Article
- Review
- Clostridioides difficile Biofilm.Advances in experimental medicine and biology · 2024Article
- Serving Two Masters: Effect ofAntibiotics (Basel, Switzerland) · 2023Article
- Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance.Communications biology · 2023Article
- Biofilms preserve the transmissibility of a multi-drug resistance plasmid.NPJ biofilms and microbiomes · 2022Article
- Biofilm antimicrobial susceptibility through an experimental evolutionary lens.NPJ biofilms and microbiomes · 2022Review
- The protective role of caffeic acid on bovine mammary epithelial cells and the inhibition of growth and biofilm formation of Gram-negative bacteria isolated from clinical mastitis milk.Frontiers in immunology · 2022Article
- Evolutionary Pathways and Trajectories in Antibiotic Resistance.Clinical microbiology reviews · 2021Article
- Sub-minimum inhibitory concentrations of biocides induced biofilm formation inNew microbes and new infections · 2020Article
- Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin.Antimicrobial agents and chemotherapy · 2018Article
- Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model.BMC microbiology · 2017Article
- Antimicrobial Activity and Resistance: Influencing Factors.Frontiers in pharmacology · 2017Review
- Experimental evolution in biofilm populations.FEMS microbiology reviews · 2016Review
- The unexhausted potential of E. coli.eLife · 2015Review
- Biofilm formation by Clostridium difficile.Gut microbesArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundExplanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes.
resultsUsing Escherichia coli biofilms, we demonstrate that heritable variation for broad-spectrum antibiotic resistance can arise and accumulate rapidly during biofilm development, even in the absence of antibiotic selection.
conclusionsOur results demonstrate the rapid de novo evolution of heritable variation in antibiotic sensitivity and resistance during E. coli biofilm development. We suggest that evolutionary processes, whether genetic drift or natural selection, should be considered as a factor to explain the elevated tolerance to antibiotics typically observed in bacterial biofilms. This could be an under-appreciated mechanism that accounts why biofilm populations are, in general, highly resistant to antibiotic treatment.
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