SynthesisBMC medical genetics2013
Association between paraoxonase gene and stroke in the Han Chinese population.
Synthesis in BMC medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Preventing effect of plant extracts and omega-3 on age-related cognitive decline in male mice.Brain, behavior, & immunity - health · 2025Article
- Evaluation of the relationship among gene expressions and enzyme activities with antioxidant role and presenilin 1 expression in Alzheimer's disease.Journal of cellular and molecular medicine · 2023Article
- Paraoxonase 1 status is a major Janus-faced component of mild and moderate acute ischemic stroke and consequent disabilities.Metabolic brain disease · 2023Article
- Article
- Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease.Drug design, development and therapy · 2023Article
- The Relationship between Cancer and Paraoxonase 1.Antioxidants (Basel, Switzerland) · 2022Review
- The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.International journal of molecular sciences · 2021Review
- Proteomics-Based Approach to Identify Novel Blood Biomarker Candidates for Differentiating Intracerebral Hemorrhage From Ischemic Stroke-A Pilot Study.Frontiers in neurology · 2021Article
- The Antioxidant Enzyme PON1: A Potential Prognostic Predictor of Acute Ischemic Stroke.Oxidative medicine and cellular longevity · 2021Article
- Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children.Antioxidants (Basel, Switzerland) · 2020Article
- Susceptibility ofPharmacogenomics and personalized medicine · 2020Article
- Identification and characterization of novel and rare susceptible variants in Indian amyotrophic lateral sclerosis patients.Neurogenetics · 2019Article
- Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study.International journal of molecular sciences · 2017Article
- Alzheimer's Disease and Paraoxonase 1 (The open biochemistry journal · 2017Article
- Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.Journal of molecular neuroscience : MN · 2015Article
- Polymorphisms in three genes are associated with hemorrhagic stroke.Brain and behavior · 2015Article
- Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.Saudi medical journal · 2015Article
- Association between PON1 L55M polymorphism and ischemic stroke: a systematic review and meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population.Molecular biology reports · 2014Article
- Paraoxonase 1 in neurological disorders.Redox report : communications in free radical research · 2014Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human paraoxonase (PON) gene family has three isoforms: PON1, PON2 and PON3. These genes are implicated as potential risk factors of cerebrovascular disease and can prevent oxidative modification of low-density lipoproteins and atherosclerosis. This study evaluated the association between the genetic variants of all three PON genes and the risks of total stroke, ischemic stroke and hemorrhagic stroke in the Han Chinese population.
methodsA total of 1016 subjects were recruited, including 508 healthy controls and 498 patients (328 with ischemic stroke and 170 with hemorrhagic stroke). A total of 11 single nucleotide polymorphisms (SNPs) covering the PON genes were genotyped for statistical analysis. Two of the 11 SNPs (rs662 and rs854560) were contextualized in a meta-analysis of ischemic stroke.
resultsThe presence of rs705381 (-162) in the promoter region of PON1 was significantly associated with total stroke (P(adjusted) = 0.0007, OR = 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (P(adjusted) = 0.0017, OR = 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke. There was also a nominal association between rs854571 (-824) and total stroke. Meta-analysis demonstrated a significant nominal association between rs662 and ischemic stroke, but there was no evidence of an association between rs662 and ischemic stroke risk in a single site association study.
conclusionsThese findings indicate that polymorphisms of PON1 gene may be a risk factor of stroke.
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