ArticleBMC infectious diseases2013
Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan Province of China.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed.
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- Subgingival biofilm colonization by Candida albicans and Candida dubliniensis in patients living with HIV from Buenos Aires, Argentina.Acta odontologica latinoamericana : AOL · 2024Article
- Antifungal and antibiofilm effects of probioticFrontiers in cellular and infection microbiology · 2024Article
- Distribution and antifungal susceptibility pattern ofVirulence · 2022Review
- Fungal esophagitis associated with tuberculous pericarditis in an human immunodeficiency virus-positive patient: a case report.Journal of medical case reports · 2022Article
- Overview on the Infections Related to RarePathogens (Basel, Switzerland) · 2022Review
- Epidemiology, prevalence, and associated factors of oral candidiasis in HIV patients from southwest Iran in post-highly active antiretroviral therapy era.Frontiers in microbiology · 2022Article
- Molecular identification of Candida isolates by Real-time PCR-high-resolution melting analysis and investigation of the genetic diversity of Candida species.Journal of clinical laboratory analysis · 2020Article
- Oral mycobiome identification in atopic dermatitis, leukemia, and HIV patients - a systematic review.Journal of oral microbiology · 2020Review
- Oral colonization by Candida species and associated factors in HIV-infected patients in Ahvaz, southwest Iran.Epidemiology and health · 2020Article
- Biofilm-ProducingHIV/AIDS (Auckland, N.Z.) · 2020Article
- Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Oral manifestations, salivary flow rates and Candida species in Thai HIV-infected patients.Journal of clinical and experimental dentistry · 2019Article
- Article
- Oropharyngeal candidiasis in HIV/AIDS patients and non-HIV subjects in the Southeast of Iran.Current medical mycology · 2018Article
- Oral colonization by Candida species in HIV-positive patients: association and antifungal susceptibility study.Einstein (Sao Paulo, Brazil) · 2018Article
- Review
- Fluconazole Resistance among Oral Candida Isolates from People Living with HIV/AIDS in a Nigerian Tertiary Hospital.Journal of fungi (Basel, Switzerland) · 2017Article
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Abstract
backgroundOral Candida colonization and its relation with predisposing factors in HIV-infected patients have received wide concerns during recent decades. In this study, we investigated asymptomatic oral Candida carriage rate, species distribution and antifungal susceptibility of 604 HIV-infected patients and 851 healthy individuals in Kunming, Yunnan Province of China.
methodsMucosal swab sampling was taken from each subject and CHROMagar Candida agar medium and API 20C AUX system were used to identify yeast isolates. In vitro antifungal susceptibility was tested by the broth microdilution method according to the M27-A2 document of the Clinical and Laboratory Standard Institute (CLSI).
resultsThe oral yeast colonization rate in HIV-infected patients (49.5%) was higher than that of healthy subjects (20.7%). Candida albicans constituted the most frequent species, accounting for 82.2% of yeast isolates. The remaining species were composed of C. glabrata, C. parapsilosis, C. krusei, C. tropicalis, C. rugosa, C. norvegensis, Pichia ohmeri and Saccharomyces cerevisiae. In HIV-infected patients, asymptomatic oral yeast colonization was associated with low CD4 cell count (<200 cells/mm3) and lack of highly active antiretroviral therapy (HAART). Different Candida species isolated from our samples presented different susceptibility to voriconazole, fluconazole and itraconazole. Amphotericin B had the best inhibiting effect for all isolates.
conclusionOral yeast colonization in Han Chinese patients with HIV from Kunming had common and unique features and was associated with CD4 cell number and HARRT. Amphotericin B should be used with first priority in controlling Candida infection in Han Chinese patients from Kunming. Our results provide first hand information on monitoring oral yeasts colonization in HIV-infected patients from Kunming, China.
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