ArticleArthritis research & therapy2013
High prevalence of spondyloarthritis and ankylosing spondylitis among familial Mediterranean fever patients and their first-degree relatives: further evidence for the connection.
Article in Arthritis research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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29 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- MEFV M694V mutation has a role in susceptibility to ankylosing spondylitis: A meta-analysis.PloS one · 2017Pooled it
- Development and implementation of the international AIDA network spondylarthritis registry.Frontiers in medicine · 2025Article
- Familial mediterranean fever in a patient with ankylosing spondylitis: could familial mediterranean fever explain a typical eight-year ankylosing spondylitis?Rheumatology international · 2024Review
- The Impact of Different MEFV Genotypes on Clinical Phenotype of Patients with Familial Mediterranean Fever: Special Emphasis on Joint Involvement.European journal of pediatrics · 2024Article
- A case of familial Mediterranean fever presenting with ankylosing spondylitis: A rare case-report.Clinical case reports · 2023Article
- [Inflammatory rheumatic diseases in migrants].Innere Medizin (Heidelberg, Germany) · 2023Review
- Mechanisms of tissue degeneration mediated by periostin in spinal degenerative diseases and their implications for pathology and diagnosis: a review.Frontiers in medicine · 2023Review
- Spondyloarthritis in familial Mediterranean fever: a cohort study.Rheumatology international · 2022Article
- Pyoderma gangrenosum in a patient with familial Mediterranean fever and chronic inflammatory seronegative arthropathy: a unique triad.BMJ case reports · 2022Article
- Familial coexistence of demyelinating diseases and familial Mediterranean fever.Rheumatology international · 2022Review
- Ankylosing spondylitis: an autoimmune or autoinflammatory disease?Nature reviews. Rheumatology · 2021Review
- Enthesitis may be one of the signs of severe disease in familial Mediterranean fever.Clinical rheumatology · 2021Article
- Real-Life Indications of Interleukin-1 Blocking Agents in Hereditary Recurrent Fevers: Data From the JIRcohort and a Literature Review.Frontiers in immunology · 2021Review
- Familial mediterranean fever: assessment of clinical manifestations, pregnancy, genetic mutational analyses, and disease severity in a national cohort.Rheumatology international · 2020Article
- Evaluation of co-existing diseases in children with familial Mediterranean fever.Rheumatology international · 2020Article
- Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study.Rheumatology international · 2020Article
- Tofacitinib for the treatment for colchicine-resistant familial Mediterranean fever: case-based review.Rheumatology international · 2020Review
- Familial Mediterranean fever: What associations to screen for?Reumatologia · 2020Review
- Evaluation of the thicknesses of cartilage and enthesis in familial Mediterranean fever and enthesitis-related arthritis.Northern clinics of Istanbul · 2020Article
- Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis.PLoS genetics · 2019Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionFamilial Mediterranean fever (FMF) is an auto-inflammatory disease characterized by recurrent attacks of fever and serositis. Limited data suggest that the prevalence of sacroiliitis is increased in patients with FMF. In our present study, we assessed the prevalence of spondyloarthritis (SpA), including ankylosing spondylitis (AS), among a cohort of FMF patients and their unaffected first-degree relatives (FDRs).
methodsThe current study cohort comprised a consecutive group of 201 unrelated patients with FMF and 319 FDRs (≥16 years old). These subjects were examined according to a standard protocol.
resultsA total of 157 FMF patients (78.1%) and 233 (73%) unaffected FDRs reported back pain. Fifteen FMF patients (7.5%) and nine unaffected FDRs fulfilled the modified New York (mNY) criteria for AS. One additional FDR with AS was identified after review of the medical records. None of the FMF patients with AS was HLA-B27 positive. The allele frequency of M694V among the FMF patients with radiographic sacroiliitis was significantly higher in comparison with those without sacroiliitis (OR 4.3). When compared with the general population, the risk ratios for SpA and AS among the FDRs of our FMF patients were 3.3 (95% CI; 2.0 to 5.5) and for AS 2.9 (95% CI; 1.3 to 6.4), respectively.
conclusionsOur study suggests that a) factors other than HLA-B27 play a role in the association of FMF and SpA/AS; b) MEFV gene variations may be one of the geographic/region-specific potential pathogenetic links between these two disorders in the Turkish population.
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