ArticlePloS one2013
Antibacterial properties of the mammalian L-amino acid oxidase IL4I1.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Advances and perspectives in genetically encoded biosensors for biomarker detection and theranostic circuits.Synthetic and systems biotechnology · 2027Review
- Synthetic closed-loop gene circuit for phenylalanine regulation.Nucleic acids research · 2025Article
- An in-depth exploration of snake venom-derived molecules for drug discovery in advancing antiviral therapeutics.Heliyon · 2024Review
- IL-4-Induced Gene 1: A Potential Player in Myocardial Infarction.Reviews in cardiovascular medicine · 2024Review
- Comparative transcriptome analysis reveals a serotype-specific immune response in Nile tilapia (Frontiers in immunology · 2024Article
- L-amino acid oxidase-1 is involved in the gut-liver axis by regulating 5-aminolevulinic acid production in mice.The Journal of veterinary medical science · 2023Article
- The transcriptomic response of bovine uterine tissue is altered in response to sperm from high- and low-fertility bulls†.Biology of reproduction · 2023Article
- Structural Determinants of the Specific Activities of an L-Amino Acid Oxidase fromMolecules (Basel, Switzerland) · 2022Article
- IL-4i1 Regulation of Immune Protection During Mycobacterium tuberculosis Infection.The Journal of infectious diseases · 2021Article
- Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity.European journal of clinical nutrition · 2021Review
- Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity.Nutrition & diabetes · 2021Review
- Antimicrobial properties of L-amino acid oxidase: biochemical features and biomedical applications.Applied microbiology and biotechnology · 2021Review
- Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis.Scientific reports · 2020Article
- Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by Salmonella Enteritidis infection.Veterinary research · 2020Article
- Review
- Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory.Scientific reports · 2018Article
- Article
- An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1.Molecules (Basel, Switzerland) · 2017Review
- Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to PulmonaryMolecular & cellular proteomics : MCP · 2017Article
- IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation.Brain : a journal of neurology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H₂O₂ and ammonia. Interleukin 4 induced gene 1 (IL4I1) is a secreted LAAO expressed by macrophages and dendritic cells stimulated by microbial derived products or interferons, which is endowed with immunoregulatory properties. It is the first LAAO described in mammalian innate immune cells. In this work, we show that this enzyme blocks the in vitro and in vivo growth of Gram negative and Gram positive bacteria. This antibiotic effect is primarily mediated by H₂O₂ production but is amplified by basification of the medium due to the accumulation of ammonia. The depletion of phenylalanine (the primary amino acid catabolized by IL4I1) may also participate in the in vivo inhibition of staphylococci growth. Thus, IL4I1 plays a distinct role compared to other antibacterial enzymes produced by mononuclear phagocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.