ArticleFrontiers in immunology2013
Active penetration of Trypanosoma cruzi into host cells: historical considerations and current concepts.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Infectivity of Aflagellar Epimastigotes ofJournal of parasitology research · 2025Article
- Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier.Journal of materials science. Materials in medicine · 2021Article
- ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity.Scientific reports · 2020Article
- Article
- Article
- Disruption of lipid rafts interferes with the interaction of Toxoplasma gondii with macrophages and epithelial cells.BioMed research international · 2014Article
- Trypanosoma cruzi-Host Cell Interaction.Frontiers in immunology · 2014Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present short review, we analyze past experiments that addressed the interactions of intracellular pathogenic protozoa (Trypanosoma cruzi, Toxoplasma gondii, and Plasmodium) with host cells and the initial use of the term active penetration to indicate that a protozoan "crossed the host cell membrane, penetrating into the cytoplasm." However, the subsequent use of transmission electron microscopy showed that, for all of the protozoans and cell types examined, endocytosis, classically defined as involving the formation of a membrane-bound vacuole, took place during the interaction process. As a consequence, the recently penetrated parasites are always within a vacuole, designated the parasitophorous vacuole (PV).
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