ArticleThe Journal of cell biology1990
Developmental regulation of mammary-derived growth inhibitor expression in bovine mammary tissue.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 70 citations in OpenAlex.
- Nutrigenomic Effect of Saturated and Unsaturated Long Chain Fatty Acids on Lipid-Related Genes in Goat Mammary Epithelial Cells: What Is the Role of PPARγ?Veterinary sciences · 2019Article
- Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion.Oncogene · 2010Article
- Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland.Transgenic research · 2000Article
- Article
- LP2, a differentiation-associated lipid-binding protein expressed in bovine lens.The Biochemical journal · 1996Article
- HH2A, an immortalized bovine mammary epithelial cell line, expresses the gene encoding mammary derived growth inhibitor (MDGI).In vitro cellular & developmental biology. Animal · 1995Article
- Members of the fatty acid binding protein family are differentiation factors for the mammary gland.The Journal of cell biology · 1994Article
- Localization of mammary-derived growth inhibitor in capillary endothelial cells of the bovine mammary gland.Cell and tissue research · 1994Article
- Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis.The EMBO journal · 1993Article
- Irregular distribution of mammary-derived growth inhibitor in the bovine mammary epithelium.Cell and tissue research · 1993Article
- Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Modulation of the beta-adrenergic-response in cultured rat heart cells. II. Mammary-derived growth inhibitor (MDGI) blocks induction of beta-adrenergic supersensitivity. Dissociation from lipid-binding activity of MDGI.Molecular and cellular biochemistry · 1991Article
- Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants.In vitro cellular & developmental biology : journal of the Tissue Culture AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cDNA for a previously described growth inhibitor, designated as mammary-derived growth inhibitor (MDGI) (Grosse, R., and P. Langen. 1989. In Handbook of Experimental Pharmacology. In press) has been cloned from a plasmid library which was derived from terminally differentiated bovine mammary gland. Sequencing of the cDNA showed an open reading frame coding for a protein of 133 amino acids. In six positions differences were found between the sequence determined from the cDNA and that determined previously by amino acid sequence analysis. Northern blot analysis revealed abundant MDGI mRNA in the terminally differentiated mammary gland, whereas in virgin gland, liver or pancreas transcripts were not expressed. By use of in situ hybridization technique transcription of MDGI in the developing bovine mammary gland was analyzed. Increasing amounts of MDGI mRNA were detected in the epithelial cells of embryonic mammary rudiment, in the epithelium of developing lobules and in terminal parts of ducts and lobuloalveolar epithelial cells of differentiated glands. There was a geographical gradient of MDGI mRNA concentration in bovine mammary gland reaching a maximum in the proximal parts of the tissue. An immunohistochemical analysis with different polyclonal and peptide directed antibodies against MDGI confirmed the in situ hybridization data with respect to the tissue-specific and differentiation-dependent MDGI expression in bovine mammary gland. The results suggest a close relationship between MDGI transcription and developmental processes in the normal bovine mammary gland.
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