Evidence map›Paper›PMID 23355630›Full record

ReviewClinical cancer research : an official journal of the American Association for Cancer Research2013

Molecular pathways: adiponectin and leptin signaling in cancer.

Michael N Vansaun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 9 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 9 syntheses or guidelines pooled it, 237 citations in OpenAlex.

  1. Pooled it
  2. Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
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  6. Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  7. Serum adiponectin levels may be associated with the pathogenesis of hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  8. Pooled it
  9. Obesity and the risk of cholangiocarcinoma: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  10. Trial
  11. Trial
  12. Review
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  17. Metabolic Health Matters More than Weight in Cancer Prevention.Journal of obesity & metabolic syndrome · 2026
    Article
  18. Article
  19. Review
  20. Review

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael N VansaunDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. michael.n.vansaun@vanderbilt.edu
Vanderbilt University Medical Center · US

Funding

Molecular Determinants of Tumor Progression in A Steatolic Liver MicroenvironmentU01CA143072 · NCI · VANDERBILT UNIVERSITY · PI GORDEN, DAVID L, MOSES, HAROLD L · 2009 to 2013
$1.4M
NCI NIH HHS 1U01CA143072-01NCI NIH HHS U01 CA143072
6 · The paper itself

Abstract

The increasing percentage of obese individuals in the population and its independent association of increased risk for the development of cancer have heightened the necessity to understand the molecular mechanisms that underlie this connection. The deregulation of adipokines in the setting of obesity and their impact on cancer progression and metastasis is one such area of research. Adipokines are bioactive proteins that mediate metabolism, inflammation, angiogenesis, and proliferation. Altered levels of adipokines or their cognate receptors in cancers can ultimately lead to an imbalance in downstream molecular pathways. Discovery of adipokine receptors in various cancers has highlighted the potential for novel therapeutic targets. Leptin and adiponectin represent two adipokines that elicit generally opposing molecular effects. Epidemiologic studies have highlighted associations between increased serum leptin levels and increased tumor growth, whereas adiponectin exhibits an inverse correlation with cancer development. This review addresses the current level of understanding of molecular pathways activated by adiponectin and leptin to identify the areas of intervention and facilitate advancement in the field.

Indexed as

Signal TransductionAdiponectinHumansLeptinModels, BiologicalNeoplasmsReceptors, AdiponectinReceptors, LeptinAdiponectinLeptinReceptors, AdiponectinReceptors, Leptin

Identifiers

PMID23355630
PMCPMC3630242
OpenAlexW2121971740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.