ArticleJournal of biomedical materials research. Part A2013
Dynamic and reversible surface topography influences cell morphology.
Article in Journal of biomedical materials research. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Review
- Production of Plant-Based, Film-Type Scaffolds Using Alginate and Corn Starch for the Culture of Bovine Myoblasts.Foods (Basel, Switzerland) · 2024Article
- Leveraging Biomaterial Platforms to Study Aging-Related Neural and Muscular Degeneration.Biomolecules · 2024Review
- Biomaterials to enhance stem cell transplantation.Cell stem cell · 2022Review
- Reversible control of biomaterial properties for dynamically tuning cell behavior.Journal of applied polymer science · 2020Article
- Surface Chemical Functionalization of Wrinkled Thiol-ene Elastomers for Promoting Cellular Alignment.ACS applied bio materials · 2020Article
- A high-throughput microfluidic method for fabricating aligned collagen fibrils to study Keratocyte behavior.Biomedical microdevices · 2019Article
- Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Synthetic scaffolds for musculoskeletal tissue engineering: cellular responses to fiber parameters.NPJ Regenerative medicine · 2019Review
- Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.Acta biomaterialia · 2017Article
- Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation.Nature communications · 2017Article
- Dynamically Tunable Cell Culture Platforms for Tissue Engineering and Mechanobiology.Progress in polymer science · 2017Article
- Temporal Modulation of Stem Cell Activity Using Magnetoactive Hydrogels.Advanced healthcare materials · 2016Article
- Convergence of Highly Resolved and Rapid Screening Platforms with Dynamically Engineered, Cell Phenotype-Prescriptive Biomaterials.Current pharmacology reports · 2016Article
- Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel.Journal of biomechanical engineering · 2016Article
- Nanotechnology in bone tissue engineering.Nanomedicine : nanotechnology, biology, and medicine · 2015Review
- A nanotopography approach for studying the structure-function relationships of cells and tissues.Cell adhesion & migration · 2015Review
- Automated, contour-based tracking and analysis of cell behaviour over long time scales in environments of varying complexity and cell density.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Microscale and nanoscale surface topography changes can influence cell functions, including morphology. Although in vitro responses to static topography are novel, cells in vivo constantly remodel topography. To better understand how cells respond to changes in topography over time, we developed a soft polyacrylamide hydrogel with magnetic nickel microwires randomly oriented in the surface of the material. Varying the magnetic field around the microwires reversibly induced their alignment with the direction of the field, causing the smooth hydrogel surface to develop small wrinkles; changes in surface roughness, ΔRRMS , ranged from 0.05 to 0.70 μm and could be oscillated without hydrogel creep. Vascular smooth muscle cell morphology was assessed when exposed to acute and dynamic topography changes. Area and shape changes occurred when an acute topographical change was imposed for substrates exceeding roughness of 0.2 μm, but longer-term oscillating topography did not produce significant changes in morphology irrespective of wire stiffness. These data imply that cells may be able to use topography changes to transmit signals as they respond immediately to changes in roughness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.