Trial reportAmerican journal of physiology. Lung cellular and molecular physiology2013
Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis.
Trial report in American journal of physiology. Lung cellular and molecular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Effect of airway clearance therapies on mucociliary clearance in adults with cystic fibrosis: A randomized controlled trial.PloS one · 2022Trial
- Effect of elexacaftor/tezacaftor/ivacaftor on mucus and mucociliary clearance in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024Observational
- Article
- Portable exhaled breath condensate metabolomics for daily monitoring of adolescent asthma.Journal of breath research · 2020Article
- Role of Cardiac AFrontiers in pharmacology · 2020Review
- Systemic inflammatory response to inhaled endotoxin does not correlate with airway response.Respiratory research · 2019Article
- Use of inhaled imipenem/cilastatin in pediatric patients with cystic fibrosis: A case series.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2019Article
- Mapping targetable inflammation and outcomes with cystic fibrosis biomarkers.Pediatric pulmonology · 2017Review
- Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate.Respiratory research · 2017Article
- Sialic acid-to-urea ratio as a measure of airway surface hydration.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Purinergic Signalling: Therapeutic Developments.Frontiers in pharmacology · 2017Review
- Article
- Applying metabolomics to uncover novel biology in ARDS.American journal of physiology. Lung cellular and molecular physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Measurement of exhaled breath condensate (EBC) biomarkers offers a noninvasive means to assess airway disease, but the ability of EBC biomarkers to track longitudinal changes in disease severity remains unproven. EBC was collected from pediatric patients with cystic fibrosis (CF) during regular clinic visits over 1 yr. EBC biomarkers urea, adenosine (Ado), and phenylalanine (Phe) were measured by mass spectrometry, and biomarker ratios were used to control for variable dilution of airway secretions. EBC biomarker ratios were assessed relative to lung function in longitudinal, multivariate models and compared with sputum inflammatory markers and quality of life assessment (CFQ-R). EBC was successfully analyzed from 51 subjects during 184 visits (3.6 ± 0.9 visits per subject). EBC Ado/urea ratio was reproducible in duplicate samples (r = 0.62, P < 0.01, n = 20) and correlated with sputum neutrophil elastase (β = 2.5, P < 0.05). EBC Ado/urea correlated with the percentage predicted of forced expiratory volume in 1 s in longitudinal, multivariate models (β = -2.9, P < 0.01); EBC Ado/Phe performed similarly (β = -2.1, P < 0.05). In contrast, IL-8 and elastase measured in spontaneously expectorated sputum (n = 57 samples from 25 subjects) and the CFQ-R respiratory scale (n = 90 tests from 47 subjects) were not significantly correlated with lung function. EBC was readily collected in a clinic setting from a wide range of subjects. EBC Ado tracked longitudinal changes in lung function in CF, with results similar to or better than established measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.