ArticleHuman mutation2013
DIP-STR: highly sensitive markers for the analysis of unbalanced genomic mixtures.
Article in Human mutation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Applicability of imprinted DIP-SNP markers in DNA mixture analysis: a pilot study.International journal of legal medicine · 2026Article
- A novel 16-plex DIP-SNP panel for forensic analysis of imbalanced DNA mixtures in a Han Chinese population.International journal of legal medicine · 2026Article
- Characterization of forensic DIP-STR markers in the admixed population of Córdoba, Argentina.International journal of legal medicine · 2026Article
- DNA Mixture Deconvolution: A Four-Strategy Framework from Physical Separation to Database Searching.Genes · 2026Review
- Genetic data and population structure of 10 DIP-STR markers across four US population groups.International journal of legal medicine · 2026Article
- Forensic genetics in the omics era.Nature reviews. Genetics · 2026Review
- Early noninvasive prenatal paternity testing by targeted fetal DNA analysis.Scientific reports · 2023Article
- Comparison between MACSprep™ forensic sperm microbead kit and Erase Sperm Isolation kit for the enrichment of sperm fractions recovered from sexual assault samples.International journal of legal medicine · 2023Article
- Application of Y-STR, DIP-STR and SNP-STR Markers inIranian journal of public health · 2022Review
- Enhanced mixture interpretation with macrohaplotypes based on long-read DNA sequencing.International journal of legal medicine · 2021Article
- Development of a multiplex methylation-sensitive restriction enzyme-based SNP typing system for deconvolution of semen-containing mixtures.International journal of legal medicine · 2021Article
- Comparison of single nucleotide polymorphisms and short tandem repeats as markers for differentiating between donors and recipients in solid organ transplantation.Korean journal of transplantation · 2021Article
- DIP-microhaplotypes: new markers for detection of unbalanced DNA mixtures.International journal of legal medicine · 2021Article
- A Novel SNP-STR System Based on a Capillary Electrophoresis Platform.Frontiers in genetics · 2021Article
- Multi-Indel: A Microhaplotype Marker Can Be Typed Using Capillary Electrophoresis Platforms.Frontiers in genetics · 2020Article
- Analysis of fetal DNA in maternal plasma with markers designed for forensic DNA mixture resolution.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Inferring biogeographic ancestry with compound markers of slow and fast evolving polymorphisms.European journal of human genetics : EJHG · 2018Article
- Separation/extraction, detection, and interpretation of DNA mixtures in forensic science (review).International journal of legal medicine · 2018Review
- Article
- Evaluation of blood, buccal swabs, and hair follicles for DNA profiling technique using STR markers.Croatian medical journal · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Samples containing highly unbalanced DNA mixtures from two individuals commonly occur both in forensic mixed stains and in peripheral blood DNA microchimerism induced by pregnancy or following organ transplant. Because of PCR amplification bias, the genetic identification of a DNA that contributes trace amounts to a mixed sample represents a tremendous challenge. This means that standard genetic markers, namely microsatellites, also referred as short tandem repeats (STR), and single-nucleotide polymorphism (SNP) have limited power in addressing common questions of forensic and medical genetics. To address this issue, we developed a molecular marker, named DIP-STR that relies on pairing deletion-insertion polymorphisms (DIP) with STR. This novel analytical approach allows for the unambiguous genotyping of a minor component in the presence of a major component, where DIP-STR genotypes of the minor were successfully procured at ratios up to 1:1,000. The compound nature of this marker generates a high level of polymorphism that is suitable for identity testing. Here, we demonstrate the power of the DIP-STR approach on an initial set of nine markers surveyed in a Swiss population. Finally, we discuss the limitations and potential applications of our new system including preliminary tests on clinical samples and estimates of their performance on simulated DNA mixtures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.