Evidence map›Paper›PMID 23355085›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2013

Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers.

Ruogang Zhao, Thomas Boudou, Wei-Gang Wang, Christopher S Chen, Daniel H Reich

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Integrating mechanical sensor readouts into organ-on-a-chip platforms.Frontiers in bioengineering and biotechnology · 2022
    Review
  14. Article
  15. Review
  16. Engineered microenvironment for the study of myofibroblast mechanobiology.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021
    Article
  17. Article
  18. Review
  19. Review
  20. Fibrosis on a Chip for Screening of Anti-Fibrosis Drugs.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruogang ZhaoDepartment of Physics and Astronomy, The Johns Hopkins University, Baltimore, MD 21218, USA.
Thomas Boudou
Wei-Gang Wang
Christopher S Chen
Daniel H Reich

Funding

Cadherins, integrins, and mechanochemical signalingR01HL073305 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S · 2003 to 2011
$3.4M
Mesenchymal Stem Cells and the MicroenvironmentR01GM074048 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S · 2006 to 2013
$2.5M
Subcellular Response to Local ForcesR01HL090747 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI REICH, DANIEL H · 2008 to 2011
$1.4M
NHLBI NIH HHS HL90747NHLBI NIH HHS R01 HL073305NHLBI NIH HHS R01 HL090747NIEHS NIH HHS P30 ES00319NIGMS NIH HHS R01 GM074048
6 · The paper itself

Abstract

A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

Indexed as

Magnetic PhenomenaMechanical PhenomenaAnimalsBiomechanical PhenomenaCollagenMiceMicrotechnologyNIH 3T3 CellsTissue EngineeringCollagen

Identifiers

PMID23355085
PMCPMC4037409

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.