ArticleParasitology research2013
Isolation, cloning, and pathologic analysis of Trypanosoma evansi field isolates.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Prevalence of bovine trypanosomiasis in Côte d'Ivoire: Systematic review and meta-analysis.The Onderstepoort journal of veterinary research · 2023Pooled it
- Systematic review and meta-analysis on the global distribution, host range, and prevalence of Trypanosoma evansi.Parasites & vectors · 2019Pooled it
- Molecular Characterization and Prevalence ofPathogens (Basel, Switzerland) · 2026Article
- Prevalence of trypanosomiasis in domesticated animals in Indonesia: A systematic review and meta-analysis.Veterinary world · 2025Review
- Molecular and phylogenetic analysis of a type K1 strainBiochemistry and biophysics reports · 2023Article
- Comparative pathology of mice infected with high and low virulence of IndonesianJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Parasitological, Hematological, and Immunological Response of Experimentally Infected Sheep with Venezuelan Isolates ofJournal of parasitology research · 2019Article
- Differential virulence of camel Trypanosoma evansi isolates in mice.Parasitology · 2018Article
- Expression of regulatory dendritic cell-related cytokines in cattle experimentally infected with Trypanosoma evansi.The Journal of veterinary medical science · 2015Article
- A panel of Trypanosoma brucei strains tagged with blue and red-shifted luciferases for bioluminescent imaging in murine infection models.PLoS neglected tropical diseases · 2014Article
- Pathogenicity of Nc-Bahia and Nc-1 strains of Neospora caninum in experimentally infected cows and buffaloes in early pregnancy.Parasitology research · 2014Article
- Trypanosoma evansi and surra: a review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the emergence of highly pathogenic Trypanosoma evansi strains in the Philippines has resulted in substantial losses in livestock production. In this study, we isolated T. evansi from infected-water buffaloes in the Philippines and analyzed their virulence using mice and cattle. A total of 10 strains of T. evansi were isolated. Evaluation of the virulence of each strain using mice depicted significant differences among the strains in the prepatent period, the level of parasitemia, and the survival time of the infected animals. In mice infected with the highly pathogenic T. evansi, signs of excessive inflammation such as marked splenomegaly and increase more than 6-fold in the number of leukocytes were observed at 8 days post-infection. To study the virulence of the parasite strains in cattle (which are the common T. evansi hosts in Philippines), cattle were infected with the T. evansi isolates that showed high and low virulence in mice. The rate of parasite growth and the length of the prepatent periods were found to be similar to those observed in mice for the respective strains. The cattle infected with the highly pathogenic strain developed anemia and a marked decrease in leukocyte counts. To determine the cause of the pathological changes, we analyzed the expression levels of inflammatory cytokines and observed up-regulation of tumor necrosis factor-α in anemic infected cattle. Our findings suggest that the epidemic of T. evansi in the Philippines is characterized by T. evansi strains with varying virulences from low to very high pathogenicity in cattle.
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