ArticleNeurosurgical review2013
Differences between middle cerebral artery bifurcations with normal anatomy and those with aneurysms.
Article in Neurosurgical review, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Biology, Physics, and Genetics of Intracranial Aneurysm Formation: A Review.Journal of neurological surgery. Part A, Central European neurosurgery · 2026Review
- Mechanical Thrombectomy for Medium Vessel Occlusion with Extracranial Vessel Tortuosity Using Quadruple Coaxial System: A Case Series.Journal of neuroendovascular therapy · 2025Article
- Morphology and variations of middle cerebral artery: systematic review and meta-analysis.Anatomy & cell biology · 2024Review
- A novel predictor of ischemic complications in the treatment of ruptured middle cerebral artery aneurysms: Neck-branching angle.World neurosurgery: X · 2024Article
- Anatomical Markers Associated With the Presence of Intracranial Aneurysms in Individuals Screened for Aneurysms.Stroke (Hoboken, N.J.) · 2024Article
- Three-Dimensional Morphometric Analysis of Anterior Cerebral Circulation Aneurysms.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Article
- Middle cerebral artery bifurcation aneurysms are associated with patient age, sex, bifurcation angle, and vascular diameters.Scientific reports · 2023Article
- The cerebral artery in cynomolgus monkeys (Macaca fascicularis).Experimental animals · 2022Article
- Artery diameter ratio after recanalization in endovascular therapy for acute ischemic stroke: a new predictor of clinical outcomes.Neuroradiology · 2022Article
- Cerebral aneurysms at major arterial bifurcations are associated with the arterial branch forming a smaller angle with the parent artery.Scientific reports · 2022Article
- Morphometry of cerebral arterial bifurcations harbouring aneurysms: a case-control study.BMC neurology · 2022Article
- A retrospective longitudinal study of age-related shifts and deformations in the basilar artery bifurcation.Neuroradiology · 2021Article
- Wall shear stress gradient is independently associated with middle cerebral artery aneurysm development: a case-control CFD patient-specific study based on 77 patients.BMC neurology · 2021Article
- Age- and gender-dependent variability in the geometry of middle cerebral artery bifurcations.Journal of anatomy · 2021Article
- Morphological parameters of middle cerebral arteries associated with aneurysm formation.Neuroradiology · 2021Article
- Neuroangiography patterns and anomalies of middle cerebral artery: A systematic review.Surgical neurology international · 2021Review
- A Hemodynamic Mechanism Correlating with the Initiation of MCA Bifurcation Aneurysms.AJNR. American journal of neuroradiology · 2020Article
- Morphological and Hemodynamic Risk Factors for Middle Cerebral Artery Aneurysm: a Case-Control Study of 190 Patients.Scientific reports · 2020Article
- Asymmetrical than symmetrical cerebral arterial bifurcations are more vulnerable to aneurysm presence.Scientific reports · 2019Article
- Asymmetrical middle cerebral artery bifurcations are more vulnerable to aneurysm formation.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objectives of this study were to elucidate the normal anatomy of middle cerebral artery (MCA) bifurcations and to analyze the differences in patients with MCA aneurysms. In the present study, 62 patients underwent three-dimensional magnetic resonance angiography, and no intracranial lesions were noted. The widths of M1 and the superior and inferior M2 branches, as well as their respective lateral angles, were measured. These values were used to calculate the daughter artery ratio (DA ratio; width of larger M2/width of smaller M2) and the lateral angle ratio (LA ratio; lateral angle between M1 and larger M2/lateral angle between M1 and smaller M2). The DA and LA ratios of 54 MCA aneurysm patients (34 with ruptured aneurysms, 20 with unruptured aneurysms) were also calculated, using three-dimensional digital subtraction angiography, and compared with the normal values. In normal patients, the widths of M1 and the branches of M2, the lateral angles, and the LA and DA ratios were not significantly different between the right and left sides. The bilateral superior and inferior lateral angles of normal MCAs were significantly wider than those of MCAs with aneurysms. The DA ratio was 1.5 ± 0.4 in normal MCAs and 1.7 ± 0.7 in MCAs with aneurysms; this difference was significant (p < 0.05). The LA ratio was 1.3 ± 0.4 in normal MCAs and 2.1 ± 1.4 in MCAs with aneurysms; these values were also significantly different (p < 0.01). Normal cerebral artery bifurcations show close to symmetric structure in the M2 branches and the lateral angles, whereas aneurysmal MCAs do not show this symmetry.
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