ArticleApplied and environmental microbiology2013
Genome instability in Lactobacillus rhamnosus GG.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
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- Genomic and Phenotypic Insight into the Probiotic Potential of Lactic Acid Bacterial spp. Associated with the Human Gut Mucosa.Probiotics and antimicrobial proteins · 2025Article
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- The insertion of the inverted repeat of an insertion sequence (IS) element fromApplied and environmental microbiology · 2025Article
- Insights from metagenome-assembled genomes on the genetic stability and safety of over-the-counter probiotic products.Current genetics · 2023Article
- In Silico Evidence of the Multifunctional Features ofFoods (Basel, Switzerland) · 2023Article
- Biochemical and Genomic Characterization of Two New Strains ofFoods (Basel, Switzerland) · 2023Article
- Challenges and opportunities of strain diversity in gut microbiome research.Frontiers in microbiology · 2023Review
- In vitro assessment of probiotic attributes for strains contained in commercial formulations.Scientific reports · 2022Article
- Persistence of the ProbioticInternational journal of molecular sciences · 2022Article
- Compositional Quality and Possible Gastrointestinal Performance of Marketed Probiotic Supplements.Probiotics and antimicrobial proteins · 2022Article
- Article
- Genomic Stability and Phenotypic Characteristics of Industrially Produced Lacticaseibacillus rhamnosus GG in a Yogurt Matrix.Applied and environmental microbiology · 2021Article
- Eco-Evolutionary Dynamics in Microbial Communities from Spontaneous Fermented Foods.International journal of environmental research and public health · 2021Article
- Article
- The Possible Link Between Manufacturing and Probiotic Efficacy; a Molecular Point of View onFrontiers in microbiology · 2021Review
- Probiotics as Adjunctive Treatment for Patients Contracted COVID-19: Current Understanding and Future Needs.Frontiers in nutrition · 2021Review
- A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria.Cell host & microbe · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe here a comparative genome analysis of three dairy product isolates of Lactobacillus rhamnosus GG (LGG) and the ATCC 53103 reference strain to the published genome sequence of L. rhamnosus GG. The analysis showed that in two of three isolates, major DNA segments were missing from the genomic islands LGGISL1,2. The deleted DNA segments consist of 34 genes in one isolate and 84 genes in the other and are flanked by identical insertion elements. Among the missing genes are the spaCBA genes, which encode pilin subunits involved in adhesion to mucus and persistence of the strains in the human intestinal tract. Subsequent quantitative PCR analyses of six commercial probiotic products confirmed that two more products contain a heterogeneous population of L. rhamnosus GG variants, including genotypes with or without spaC. These results underline the relevance for quality assurance and control measures targeting genome stability in probiotic strains and justify research assessing the effect of genetic rearrangements in probiotics on the outcome of in vitro and in vivo efficacy studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.