ArticleApplied and environmental microbiology2013
Anaerobic sulfur metabolism coupled to dissimilatory iron reduction in the extremophile Acidithiobacillus ferrooxidans.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 154 citations in OpenAlex.
- Comparative Genomic Analysis Reveals Distribution, Organization, and Evolution of Ferrous and Sulfur Oxidation Genes in the GenusInternational journal of molecular sciences · 2026Article
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- Overexpression of sulfide:quinone reductase (SQR) inApplied and environmental microbiology · 2025Article
- The potential for coupled organic and inorganic sulfur cycles across the terrestrial deep subsurface biosphere.Nature communications · 2025Article
- Biogenic Sulfide-Mediated Iron Reduction at Low pH.Microorganisms · 2024Article
- Multi-omics analyses provide insights into the sulfur metabolism of a novel deep-sea sulfate-reducing bacterium.iScience · 2024Article
- Characterize the Growth and Metabolism ofMicroorganisms · 2024Article
- Goethite dissolution by acidophilic bacteria.Frontiers in microbiology · 2024Article
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- Microbial Ecosystems in Movile Cave: An Environment of Extreme Life.Life (Basel, Switzerland) · 2023Article
- Fe/S Redox-Coupled Mercury Transformation Mediated byMicroorganisms · 2023Article
- Eurypsychrophilic acidophiles: From (meta)genomes to low-temperature biotechnologies.Frontiers in microbiology · 2023Review
- Generation and Physiology of Hydrogen Sulfide and Reactive Sulfur Species in Bacteria.Antioxidants (Basel, Switzerland) · 2022Review
- Winogradsky Bioelectrochemical System as a Novel Strategy to Enrich Electrochemically Active Microorganisms from Arsenic-Rich Sediments.Micromachines · 2022Article
- Deep-SeamBio · 2022Article
- Genomic evolution of the class Acidithiobacillia: deep-branching Proteobacteria living in extreme acidic conditions.The ISME journal · 2021Article
- Genomic Insights into the Ecological Role and Evolution of a NovelApplied and environmental microbiology · 2021Article
- The Microbiology of Metal Mine Waste: Bioremediation Applications and Implications for Planetary Health.GeoHealth · 2021Review
- Exobiology of the Venusian Clouds: New Insights into Habitability through Terrestrial Models and Methods of Detection.Astrobiology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene transcription (microarrays) and protein levels (proteomics) were compared in cultures of the acidophilic chemolithotroph Acidithiobacillus ferrooxidans grown on elemental sulfur as the electron donor under aerobic and anaerobic conditions, using either molecular oxygen or ferric iron as the electron acceptor, respectively. No evidence supporting the role of either tetrathionate hydrolase or arsenic reductase in mediating the transfer of electrons to ferric iron (as suggested by previous studies) was obtained. In addition, no novel ferric iron reductase was identified. However, data suggested that sulfur was disproportionated under anaerobic conditions, forming hydrogen sulfide via sulfur reductase and sulfate via heterodisulfide reductase and ATP sulfurylase. Supporting physiological evidence for H2S production came from the observation that soluble Cu(2+) included in anaerobically incubated cultures was precipitated (seemingly as CuS). Since H(2)S reduces ferric iron to ferrous in acidic medium, its production under anaerobic conditions indicates that anaerobic iron reduction is mediated, at least in part, by an indirect mechanism. Evidence was obtained for an alternative model implicating the transfer of electrons from S(0) to Fe(3+) via a respiratory chain that includes a bc(1) complex and a cytochrome c. Central carbon pathways were upregulated under aerobic conditions, correlating with higher growth rates, while many Calvin-Benson-Bassham cycle components were upregulated during anaerobic growth, probably as a result of more limited access to carbon dioxide. These results are important for understanding the role of A. ferrooxidans in environmental biogeochemical metal cycling and in industrial bioleaching operations.
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