ArticleAnnals of biomedical engineering2013
Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Target, Treat, and Track: Superparamagnetic Iron Oxide Nanoparticles (SPION) Driven Theranostic Delivery of Antimicrobials to the Lungs.Nanotechnology, science and applications · 2025Review
- Alveolar distribution of nebulized solution in health and lung injury assessed by confocal microscopy.Physiological reports · 2024Article
- Article
- Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Imaging drug delivery to the lungs: Methods and applications in oncology.Advanced drug delivery reviews · 2023Review
- An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2-From Raw MOF to Drug Delivery System.Pharmaceutics · 2019Article
- Effects of Partial Gravity on the Function and Particle Handling of the Human Lung.Current pathobiology reports · 2018Article
- Iron-Based Metal-Organic Frameworks as a Theranostic Carrier for Local Tuberculosis Therapy.Pharmaceutical research · 2018Article
- Novel multi-functional europium-doped gadolinium oxide nanoparticle aerosols facilitate the study of deposition in the developing rat lung.Nanoscale · 2016Article
- Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.Journal of molecular histology · 2016Article
- Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data.Pharmaceutical research · 2015Article
- Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies.Journal of biomechanics · 2015Article
- Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes.Particle and fibre toxicology · 2014Article
- MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Aerosol deposition in the human lung in reduced gravity.Journal of aerosol medicine and pulmonary drug delivery · 2014Review
- Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments.Annals of biomedical engineering · 2014Article
- Heterogeneity and matching of ventilation and perfusion within anatomical lung units in rats.Respiratory physiology & neurobiology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The toxic or therapeutic effect of an inhaled aerosol is highly dependent upon the site and extent of deposition in the lung. A novel MRI-based method was used to quantify the spatial distribution of particles in the rat lung. Rats were exposed to 0.95 μm-diameter iron oxide particles in a controlled manner (N = 6) or to particle-free air (N = 6). Lungs were fixed in 3% glutaraldehyde by vascular perfusion, excised and imaged in a 3T scanner using a gradient-echo imaging protocol. The signal decay rate, R2*, was measured in each voxel of the entire left lung (1 mm thick slices). R2* was significantly higher in exposed animals (0.0065 ± 0.0006 ms(-1)) than in controls (0.0050 ± 0.0003 ms(-1), p < 0.001). A calibration curve between R2* and concentration of deposited particles (C(part)) was obtained by imaging gel samples with known particle concentrations. Regional deposition was assessed by comparing C(part) between the outer (C(part,peripheral)) and inner (C(part,central)) areas on each transaxial slice, and expressed as the c/p ratio. C(part,peripheral) (1.54 ± 0.70 μg/mL) was significantly higher than C(part,central) (1.00 ± 0.39 μg/mL, p<0.05), resulting in a c/p ratio of 0.65. This method may be used in future studies to quantify spatial distribution of deposited particles in healthy and diseased lungs.
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