ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Evaluation of right ventricular volume and ejection fraction by gated (18)F-FDG PET in patients with pulmonary hypertension: comparison with cardiac MRI and CT.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cardiac CT for Measurement of Right Ventricular Volume and Function in Comparison with Cardiac MRI: A Meta-Analysis.Korean journal of radiology · 2020Pooled it
- CT compared to MRI for functional evaluation of the right ventricle: a systematic review and meta-analysis.European radiology · 2019Pooled it
- An official American Thoracic Society Statement: pulmonary hypertension phenotypes.American journal of respiratory and critical care medicine · 2014Guideline
- Role of PET imaging in evaluating right ventricular function and prognosis in pulmonary hypertension.Clinics (Sao Paulo, Brazil) · 2026Review
- Effects of ranolazine on right ventricular function, fluid dynamics, and metabolism in patients with precapillary pulmonary hypertension: insights from a longitudinal, randomized, double-blinded, placebo controlled, multicenter study.Frontiers in cardiovascular medicine · 2023Article
- Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.Cardiovascular diagnosis and therapy · 2020Review
- Right ventricular dyssynchrony in pulmonary hypertension: Phase analysis using FDG-PET imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- The characterization and prognostic significance of right ventricular glucose metabolism in non-ischemic dilated cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Positron emission tomography: An additional prognostic tool in dilated cardiomyopathy?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Thoracic [18F]fluorodeoxyglucose uptake measured by positron emission tomography/computed tomography in pulmonary hypertension.Medicine · 2016Observational
- A feasible method for non-invasive measurement of pulmonary vascular resistance in pulmonary arterial hypertension: Combined use of transthoracic Doppler-echocardiography and cardiac magnetic resonance. Non-invasive estimation of pulmonary vascular resistance.International journal of cardiology. Heart & vasculature · 2015Article
- Sample size considerations for clinical research studies in nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Growing applications of FDG PET-CT imaging in non-oncologic conditions.Journal of biomedical research · 2015Article
- The role of nuclear imaging in pulmonary hypertension.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- FDG PET imaging for identifying pulmonary hypertension and right heart failure.Current cardiology reports · 2015Review
- The role of PET quantification in cardiovascular imaging.Clinical and translational imaging · 2014Article
- Biomarkers for pediatric pulmonary arterial hypertension - a call to collaborate.Frontiers in pediatrics · 2014Review
- Metabolic and Functional Evaluation of the Heart and Lungs in Pulmonary Hypertension by Gated 2-[18F]-Fluoro-2-deoxy-D-glucose Positron Emission Tomography.Pulmonary circulationArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundRight ventricular (RV) function is a powerful predictor of survival in patients with pulmonary hypertension (PH), but noninvasively assessing RV function remains a challenge. The aim of this study was to prospectively compare gated (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) myocardial imaging (gated PET), cardiac magnetic resonance (CMR), and cardiac computed tomography (CCT) for the assessment of RV volume and ejection fraction in patients with PH.
methodsTwenty-three consecutive patients aged more than 16 years diagnosed with PH were included. All patients underwent gated PET, CMR, and CCT within 7 days. Right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV), and right ventricular ejection fraction (RVEF) were calculated by three imaging modalities. RV (18)F-FDG uptake was determined as RV-corrected standardized uptake value (SUV), and the ratio of RV to left ventricular (LV)-corrected SUV (Corrected SUV R/L).
resultsGated PET showed a moderate correlation (r = 0.680, P < .001) for RVEDV, good correlation for RVESV (r = 0.757, P < .001) and RVEF (r = 0.788, P < .001) with CMR, and good correlation for RVEDV (r = 0.767, P < .001), RVESV (r = 0.837, P < .001), and RVEF (r = 0.730, P < .001) with CCT. Bland-Altman analysis revealed systematic underestimation of RVEDV and RVESV and overestimation of RVEF with gated PET compared with CMR and CCT. The correlation between RVESV (r = 0.863, P < .001), RVESV (r = 0.903, P < .001), and RVEF (r = 0.853, P < .001) of CMR and those of CCT was excellent; Bland-Altman analysis showed only a slight systematic variation between CMR and CCT. There were statistically significant negative correlations between RV-corrected SUV and RVEF-CMR (r = -0.543, P < .01), Corrected SUV R/L and RVEF-CMR (r = -0.521, P < .05), RV-corrected SUV and RVEF-CCT (r = -0.429, P < .05), Corrected SUV R/L and RVEF-CCT (r = -0.580, P < .01), respectively.
conclusionGated PET had moderate-to-high correlation with CMR and CCT in the assessments of RV volume and ejection fraction. It is an available method for simultaneous assessing of RV function and myocardial glucose metabolism in patients with PH.
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Registered trials
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