Trial reportDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2013
[Topical hemoglobin promotes wound healing of patients with venous leg ulcers].
Trial report in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Systematic review of the efficacy of topical haemoglobin therapy for wound healing.International wound journal · 2020Pooled it
- Dressings and topical agents for treating venous leg ulcers.The Cochrane database of systematic reviews · 2018Pooled it
- Oxygenation Status in Chronic Leg Ulcer After Topical Hemoglobin Application May Act as a Surrogate Marker to Find the Best Treatment Strategy and to Avoid Ineffective Conservative Long-term Therapy.Molecular imaging and biology · 2018Trial
- A breath of fresh air: the role of oxygen carriers in plastic surgery.Frontiers in bioengineering and biotechnology · 2026Review
- Topical oxygen therapy and singlet oxygen in wound healing: A scoping review.International wound journal · 2024Article
- Hemoglobin spray as adjunct therapy in complex wounds: Meta-analysis versus standard care alone in pooled data by wound type across three retrospective cohort controlled evaluations.SAGE open medicine · 2018Review
- Clinical effectiveness of hemoglobin spray (GranuloxDiabetic foot & ankle · 2016Article
- Wound management with compression therapy and topical hemoglobin solution in a patient with Budd-Chiari Syndrome.Journal of dermatological case reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImprovement of oxygenation is getting increasing attention as an important aspect in the modern wound care. The aim of such complementary wound care approaches is to improve and accelerate wound healing. PATIENTS AND
methodsA solution comprising purified hemoglobin was added to the standard wound care procedure of patients with venous leg ulcers and compared to a second group without addition of the hemoglobin. In each group, 36 patients were included. The duration of treatment was 13 weeks. Primary end point was reduction of wound size or wound closing.
resultsIn the group treated with the additional hemoglobin solution, an average of 53% of wound size reduction was obtained. No statistically significant reduction was observed in the second group.
conclusionThe addition of aemoglobin solution in the wound care procedure for venous leg ulcers showed a significant improvement of wound healing in comparison to a control group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.