ArticleJournal of the American Society for Mass Spectrometry2013
Gas-phase reactivity of peptide thiyl (RS•), perthiyl (RSS•), and sulfinyl (RSO•) radical ions formed from atmospheric pressure ion/radical reactions.
Article in Journal of the American Society for Mass Spectrometry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Experimental and Computational Investigation of Sulfur Chemistry in the DART-MS Gas Stream: Implications for the Interpretation of the Mass Spectra of Organic Disulfides.Journal of the American Society for Mass Spectrometry · 2026Article
- Expedient Synthesis of Substituted Thieno[3,2-Molecules (Basel, Switzerland) · 2024Article
- Two-step reaction mechanism reveals new antioxidant capability of cysteine disulfides against hydroxyl radical attack.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A distonic radical-ion for detection of traces of adventitious molecular oxygen (O2) in collision gases used in tandem mass spectrometers.Journal of the American Society for Mass Spectrometry · 2014Article
- Reactions of hydroxyalkyl radicals with cysteinyl peptides in a nanoESI plume.Journal of the American Society for Mass Spectrometry · 2014Article
- Radical additions to aromatic residues in peptides facilitate unexpected side chain and backbone losses.Journal of the American Society for Mass Spectrometry · 2014Article
- Characterization of a DAPI-RIT-DAPI system for gas-phase ion/molecule and ion/ion reactions.Journal of the American Society for Mass Spectrometry · 2014Article
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2 authors.
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Abstract
In this study, we demonstrated the formation of gas-phase peptide perthiyl (RSS•) and thiyl (RS•) radical ions besides sulfinyl radical (RSO•) ions from atmospheric pressure (AP) ion/radical reactions of peptides containing inter-chain disulfide bonds. The identity of perthiyl radical was verified from characteristic 65 Da (•SSH) loss in collision-induced dissociation (CID). This signature loss was further used to assess the purity of peptide perthiyl radical ions formed from AP ion/radical reactions. Ion/molecule reactions combined with CID were carried out to confirm the formation of thiyl radical. Transmission mode ion/molecule reactions in collision cell (q2) were developed as a fast means to estimate the population of peptide thiyl radical ions. The reactivity of peptide thiyl, perthiyl, and sulfinyl radical ions was evaluated based on ion/molecule reactions toward organic disulfides, allyl iodide, organic thiol, and oxygen, which followed in order of thiyl (RS•) > perthiyl (RSS•) > sulfinyl (RSO•). The gas-phase reactivity of these three types of sulfur-based radicals is consistent with literature reports from solution studies.
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