ArticleNature cell biology2013
Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts.
Article in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Unraveling the molecular details of centriole elongation.Trends open · 2026Article
- CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.Genes & development · 2026Article
- Asymmetric centromere and gene locus positioning inbioRxiv : the preprint server for biology · 2025Article
- Asymmetry of centrosomes inMolecular biology of the cell · 2025Article
- Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle.Scientific reports · 2025Article
- Article
- Catalytic growth in a shared enzyme pool ensures robust control of centrosome size.bioRxiv : the preprint server for biology · 2024Article
- Centrosome age breaks spindle size symmetry even in cells thought to divide symmetrically.The Journal of cell biology · 2024Article
- Imaging and Analysis of Drosophila Neural Stem Cell Asymmetric Division.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Live-Cell Imaging of Drosophila melanogaster Third Instar Larval Brains.Journal of visualized experiments : JoVE · 2023Article
- APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.EMBO reports · 2023Article
- Asymmetric Histone Inheritance: Establishment, Recognition, and Execution.Annual review of genetics · 2022Review
- Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo.Communications biology · 2022Article
- Pericentrin interacts with Kinesin-1 to drive centriole motility.The Journal of cell biology · 2022Article
- Multifaceted roles of centrosomes in development, health, and disease.Journal of molecular cell biology · 2021Review
- Centrosome instability: when good centrosomes go bad.Cellular and molecular life sciences : CMLS · 2021Review
- TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.The Journal of cell biology · 2021Article
- A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding.Nature communications · 2021Article
- Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer.Oncotarget · 2021Article
- Centrosome-centric view of asymmetric stem cell division.Open biology · 2021Review
13 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
During interphase in Drosophila neuroblasts, the Centrobin (CNB)-positive daughter centriole retains pericentriolar material (PCM) and organizes an aster that is a key determinant of the orientation of cell division. Here we show that daughter centrioles depleted of CNB cannot fulfil this function whereas mother centrioles that carry ectopic CNB can. CNB co-precipitates with a set of centrosomal proteins that include γ-TUB, ANA2, CNN, SAS-4, ASL, DGRIP71, POLO and SAS-6. Following chemical inhibition of POLO or removal of three POLO phosphorylation sites present in CNB, the interphase microtubule aster is lost. These results demonstrate that centriolar CNB localization is both necessary and sufficient to enable centrioles to retain PCM and organize the interphase aster in Drosophila neuroblasts. They also reveal an interphase function for POLO in this process that seems to have co-opted part of the protein network involved in mitotic centrosome maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.