ArticleBehavioural brain research2013
Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: reversal by D1 receptor antagonist administration.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats.The international journal of neuropsychopharmacology · 2024Article
- Pramipexole Hyperactivates the External Globus Pallidus and Impairs Decision-Making in a Mouse Model of Parkinson's Disease.International journal of molecular sciences · 2024Article
- Motor impulsivity but not risk-related impulsive choice is associated to drug intake and drug-primed relapse.Frontiers in behavioral neuroscience · 2023Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Article
- Dissociable roles for the ventral and dorsal medial prefrontal cortex in cue-guided risk/reward decision making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Contribution of the prefrontal cortex and basolateral amygdala to behavioral decision-making under reward/punishment conflict.Psychopharmacology · 2020Article
- The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Neurons in rat orbitofrontal cortex and medial prefrontal cortex exhibit distinct responses in reward and strategy-update in a risk-based decision-making task.Metabolic brain disease · 2019Article
- Long-term deficits in risky decision-making after traumatic brain injury on a rat analog of the Iowa gambling task.Brain research · 2019Article
- Review: brain neurobiology of gambling disorder based on rodent models.Neuropsychiatric disease and treatment · 2019Review
- Contributions of medial prefrontal cortex to decision making involving risk of punishment.Neuropharmacology · 2018Article
- Dopamine and Stress System Modulation of Sex Differences in Decision Making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task.Psychopharmacology · 2015Article
- Cocaine choice procedures in animals, humans, and treatment-seekers: Can we bridge the divide?Pharmacology, biochemistry, and behavior · 2015Review
- Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task.Psychopharmacology · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Decision-making is a complex cognitive process that is impaired in a number of psychiatric disorders. In the laboratory, decision-making is frequently assessed using "gambling" tasks that are designed to simulate real-life decisions in terms of uncertainty, reward and punishment. Here, we investigate whether lesions of the medial prefrontal cortex (PFC) cause impairments in decision-making using a rodent gambling task (rGT). In this task, rats have to decide between 1 of 4 possible options: 2 options are considered "advantageous" and lead to greater net rewards (food pellets) than the other 2 "disadvantageous" options. Once rats attained stable levels of performance on the rGT they underwent sham or excitoxic lesions of the medial PFC and were allowed to recover for 1 week. Following recovery, rats were retrained for 5 days and then the effects of a dopamine D1-like receptor antagonist (SCH23390) or a D2-like receptor antagonist (haloperidol) on performance were assessed. Lesioned rats exhibited impaired decision-making: they made fewer advantageous choices and chose the most optimal choice less frequently than did sham-operated rats. Administration of SCH23390 (0.03 mg/kg), but not haloperidol (0.015-0.03 mg/kg) attenuated the lesion-induced decision-making deficit. These results indicate that the medial PFC is important for decision-making and that excessive signaling at D1 receptors may contribute to decision-making impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.