ArticleBiomedical materials (Bristol, England)2013
Highly charged cyanine fluorophores for trafficking scaffold degradation.
Article in Biomedical materials (Bristol, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems.Light, science & applications · 2025Article
- Tumor Targeting with Methotrexate-Conjugated Zwitterionic Near-Infrared Fluorophore for Precise Photothermal Therapy.International journal of molecular sciences · 2022Article
- Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.International journal of molecular sciences · 2022Article
- Rapid Tumor Targeting of Renal-Clearable ZW800-1 Conjugate for Efficient Photothermal Cancer Therapy.Biomedicines · 2021Article
- Non-invasive in vivo monitoring of transplanted stem cells in 3D-bioprinted constructs using near-infrared fluorescent imaging.Bioengineering & translational medicine · 2021Article
- 3D Printing and NIR Fluorescence Imaging Techniques for the Fabrication of Implants.Materials (Basel, Switzerland) · 2020Review
- Effects of physical orientation of dye molecules and molecular orbitals on performance of solid-state dye sensitized solar cells.Materials today. Proceedings · 2020Article
- Second Generation G-Quadruplex Stabilizing Trimethine Cyanines.Bioconjugate chemistry · 2019Article
- Real-Time Fluorescence Imaging in Thoracic Surgery.The Korean journal of thoracic and cardiovascular surgery · 2019Article
- Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- Tissue-Specific Near-Infrared Fluorescence Imaging.Accounts of chemical research · 2016Article
- Endocrine-specific NIR fluorophores for adrenal gland targeting.Chemical communications (Cambridge, England) · 2016Article
- Tailoring cyanine dark states for improved optically modulated fluorescence recovery.The journal of physical chemistry. B · 2015Article
- Photoinduced dynamics of a cyanine dye: parallel pathways of non-radiative deactivation involving multiple excited-state twisted transients.Chemical science · 2015Article
- Pre-clinical characterization of tissue engineering constructs for bone and cartilage regeneration.Annals of biomedical engineering · 2015Review
- Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores.RSC advances · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Biodegradable scaffolds have been extensively used in the field of tissue engineering and regenerative medicine. However, noninvasive monitoring of in vivo scaffold degradation is still lacking. In order to develop a real-time trafficking technique, a series of meso-brominated near-infrared (NIR) fluorophores were synthesized and conjugated to biodegradable gelatin scaffolds. Since the pentamethine cyanine core is highly lipophilic, the side chain of each fluorophore was modified with either quaternary ammonium salts or sulfonate groups. The physicochemical properties such as lipophilicity and net charge of fluorophores played a key role in the fate of NIR-conjugated scaffolds in vivo after biodegradation. The positively charged fluorophore-conjugated scaffold fragments were found in salivary glands, lymph nodes, and most of the hepatobiliary excretion route. However, halogenated fluorophores intensively accumulated into lymph nodes and the liver. Interestingly, balanced-charged gelatin scaffolds were degraded into urine in a short period of time. These results demonstrate that the noninvasive optical imaging using NIR fluorophores can be useful for the translation of biodegradable scaffolds into the clinic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.