ArticleOsteoarthritis and cartilage2013
Relationship between anisotropic diffusion properties and tissue morphology in porcine TMJ disc.
Article in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Bridging Temporomandibular Joint Structure, Function, and Pain: An Integrated Multiscale Perspective.Journal of dental research · 2026Review
- Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs.JOR spine · 2024Article
- Viable Vitreous Grafts of Whole Porcine Menisci for Transplant in the Knee and Temporomandibular Joints.Advanced healthcare materials · 2024Article
- Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue.PloS one · 2024Article
- Diffusivity of Human Cartilage Endplates in Healthy and Degenerated Intervertebral Disks.Journal of biomechanical engineering · 2023Article
- Strain-Dependent Diffusivity of Small and Large Molecules in Meniscus.Journal of biomechanical engineering · 2022Article
- A noninvasive fluorescence imaging-based platform measures 3D anisotropic extracellular diffusion.Nature communications · 2021Article
- EFFECTS OF SOLUTE SIZE AND TISSUE COMPOSITION ON MOLECULAR AND MACROMOLECULAR DIFFUSIVITY IN HUMAN KNEE CARTILAGE.Osteoarthritis and cartilage open · 2020Article
- Molecular and macromolecular diffusion in human meniscus: relationships with tissue structure and composition.Osteoarthritis and cartilage · 2020Article
- On the characterization of interstitial fluid flow in the skeletal muscle endomysium.Journal of the mechanical behavior of biomedical materials · 2020Article
- Mechanobehavior and Ontogenesis of the Temporomandibular Joint.Journal of dental research · 2018Review
- Regionally variant collagen alignment correlates with viscoelastic properties of the disc of the human temporomandibular joint.Archives of oral biology · 2018Article
- The Yucatan Minipig Temporomandibular Joint Disc Structure-Function Relationships Support Its Suitability for Human Comparative Studies.Tissue engineering. Part C, Methods · 2017Article
- Structure-Function Relationships of Temporomandibular Retrodiscal Tissue.Journal of dental research · 2017Article
- Tensile biomechanical properties of human temporomandibular joint disc: Effects of direction, region and sex.Journal of biomechanics · 2016Article
- The effects of oxygen level and glucose concentration on the metabolism of porcine TMJ disc cells.Osteoarthritis and cartilage · 2015Article
- Viscoelastic shear properties of porcine temporomandibular joint disc.Orthodontics & craniofacial research · 2015Article
- Controlled release for local delivery of drugs: barriers and models.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Measurement of three-dimensional anisotropic diffusion by multiphoton fluorescence recovery after photobleaching.Annals of biomedical engineering · 2014Article
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5 authors.
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Abstract
objectiveTo investigate the relationship between anisotropic solute diffusion properties and tissue morphology in porcine temporomandibular joint (TMJ) discs.
designTMJ discs from eleven pigs aged 6-8 months were divided into five regions: anterior, intermediate, posterior, lateral, and medial. The transport properties and tissue morphology were investigated in three orthogonal orientations: anteroposterior (AP), mediolateral (ML), and superoinferior (SI). The anisotropic diffusivity of fluorescein (332 Da) in the right discs was determined by the fluorescence recovery after photobleaching (FRAP) protocols. The tissue morphology in the left discs was quantified by scanning electron microscopy.
resultsThe diffusivities of fluorescein in the TMJ disc were significantly anisotropic, except for the anterior region. In the medial, intermediate, and lateral regions, the diffusion along the fiber orientation (i.e., AP direction) was significantly faster than the diffusion in ML and SI directions. In the posterior region, the diffusion along the fiber orientation (i.e., ML direction) was significantly faster than the diffusion in AP and SI directions. The diffusion in the anterior region was mostly isotropic with the lowest degree of diffusion anisotropy, as well as collagen fiber alignment, likely due to the multi-directional fiber arrangement. The anterior region had the highest mean diffusivity [65.6 (49.3-81.8) μm(2)/s] in the disc, likely due to its high water content. The overall average diffusivity of fluorescein across the TMJ disc was 57.0 (43.0-71.0) μm(2)/s.
conclusionsThe solute diffusion in porcine TMJ discs was strongly anisotropic and inhomogeneous, which associated with tissue structure (i.e., collagen fiber alignment) and composition (e.g., water content).
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