ArticleBiomedical materials (Bristol, England)2013
Fabrication and characterization of multiscale electrospun scaffolds for cartilage regeneration.
Article in Biomedical materials (Bristol, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Multilayered electrospun scaffolds for tendon tissue engineering.Tissue engineering. Part A · 2013Trial
- Digital light processing of hydrogel molds to guide cell mechanosensing and the fabrication of meniscal tissue constructs.APL bioengineering · 2025Article
- Advancing cancer research through 3D cell culture models.EXCLI journal · 2025Review
- Recent advances in bionic scaffolds for cartilage tissue engineering.Frontiers in bioengineering and biotechnology · 2025Review
- Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective.Nanotheranostics · 2023Review
- Influence of Fiber Stiffness on Meniscal Cell Migration into Dense Fibrous Networks.Advanced healthcare materials · 2020Article
- Electrospun Polymers in Cartilage Engineering-State of Play.Frontiers in bioengineering and biotechnology · 2020Review
- Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds.Tissue engineering. Part C, Methods · 2019Article
- Repair of Damaged Articular Cartilage: Current Approaches and Future Directions.International journal of molecular sciences · 2018Review
- Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication.International journal of molecular sciences · 2018Review
- Recent Progress of Fabrication of Cell Scaffold by Electrospinning Technique for Articular Cartilage Tissue Engineering.International journal of biomaterials · 2018Review
- Electrospun poly(N-isopropyl acrylamide)/poly(caprolactone) fibers for the generation of anisotropic cell sheets.Biomaterials science · 2017Article
- Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies.Engineering (Beijing, China) · 2017Article
- Enhancing cell infiltration of electrospun fibrous scaffolds in tissue regeneration.Bioactive materials · 2016Review
- Bioimaging: An Useful Tool to Monitor Differentiation of Human Embryonic Stem Cells into Chondrocytes.Annals of biomedical engineering · 2016Article
- Potential of Electrospun Nanofibers for Biomedical and Dental Applications.Materials (Basel, Switzerland) · 2016Review
- Aligned multilayered electrospun scaffolds for rotator cuff tendon tissue engineering.Acta biomaterialia · 2015Article
- Open-source three-dimensional printing of biodegradable polymer scaffolds for tissue engineering.Journal of biomedical materials research. Part A · 2014Article
- Direct and indirect co-culture of chondrocytes and mesenchymal stem cells for the generation of polymer/extracellular matrix hybrid constructs.Acta biomaterialia · 2014Article
- Cell-derived polymer/extracellular matrix composite scaffolds for cartilage regeneration, Part 2: construct devitalization and determination of chondroinductive capacity.Tissue engineering. Part C, Methods · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Recently, scaffolds for tissue regeneration purposes have been observed to utilize nanoscale features in an effort to reap the cellular benefits of scaffold features resembling extracellular matrix (ECM) components. However, one complication surrounding electrospun nanofibers is limited cellular infiltration. One method to ameliorate this negative effect is by incorporating nanofibers into microfibrous scaffolds. This study shows that it is feasible to fabricate electrospun scaffolds containing two differently scaled fibers interspersed evenly throughout the entire construct as well as scaffolds containing fibers composed of two discrete materials, specifically fibrin and poly(ε-caprolactone). In order to accomplish this, multiscale fibrous scaffolds of different compositions were generated using a dual extrusion electrospinning setup with a rotating mandrel. These scaffolds were then characterized for fiber diameter, porosity and pore size and seeded with human mesenchymal stem cells to assess the influence of scaffold architecture and composition on cellular responses as determined by cellularity, histology and glycosaminoglycan (GAG) content. Analysis revealed that nanofibers within a microfiber mesh function to maintain scaffold cellularity under serum-free conditions as well as aid the deposition of GAGs. This supports the hypothesis that scaffolds with constituents more closely resembling native ECM components may be beneficial for cartilage regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.