ArticleBiochemical and biophysical research communications2013
Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.
Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Exploring Astyanax mexicanus as a model for unraveling genotype-environment interactions and metabolic adaptations.Lab animal · 2026Review
- Reproductive toxicity of DDT in the Japanese medaka fish model: Revisiting the impacts of DDT+ on female reproductive health.Chemosphere · 2024Review
- High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat.American journal of physiology. Renal physiology · 2022Article
- The Developmental and Genetic Architecture of the Sexually Selected Male Ornament of Swordtails.Current biology : CB · 2021Article
- Impact of early-life diet on long-term renal health.Molecular and cellular pediatrics · 2020Review
- Intact in vivo visualization of telencephalic microvasculature in medaka using optical coherence tomography.Scientific reports · 2020Article
- Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease.FEBS open bio · 2019Article
- Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model.Physiological reports · 2019Article
- Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease.Biochemistry and biophysics reports · 2018Article
- Growth of rare minnows (Gobiocypris rarus) fed different amounts of dietary protein and lipids.Lab animal · 2016Article
- Workshop report: The medaka model for comparative assessment of human disease mechanisms.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Article
- A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures.Biochemical and biophysical research communications · 2015Article
- The glomerular parietal epithelial cell's responses are influenced by SM22 alpha levels.BMC nephrology · 2014Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Obesity, an ongoing significant public health problem, is a part of complex disease characterized as metabolic syndrome. Medaka and zebrafish are useful aquatic experimental animals widely used in the field of toxicology and environmental health sciences and as a human disease models. In medaka, simple feeding of a high fat diet (HFD) can induce body weight gain, excessive accumulation of visceral adipose tissue, hyperglycemia, hyperlipidemia, and steatohepatitis, which mimics human metabolic syndrome. In the present study, to explore the possibility that the adult medaka fed with HFD (HFD-medaka) can be used as an animal model for human metabolic syndrome-associated glomerular disease, including obesity-related glomerulopathy (ORG), we analyzed structural alterations and protein expression in the mesonephric kidney of HFD-medaka. We found that the histopathology was consistent with glomerulomegaly accompanied by the dilation of glomerular capillaries and proliferative expansion of the mesangium, a condition partially comparable to human ORG. Moreover, expressions of several kinds of kidney disease-related proteins (such as MYH9, SM22α) were significantly elevated. Thus, the HFD-medaka has a high potential as an animal model useful for exploring the mechanism underling human ORG.
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