ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2013
Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.
Review in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 121 citations in OpenAlex.
- An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects.BMC complementary and alternative medicine · 2014Trial
- Hepatoprotective Activity of Red Ginger Extract on Acetaminophen-induced Liver Injury Models in HepG2 Cells.Annals of African medicine · 2025Article
- Therapeutic potential of plant-derived natural products against drug-induced liver injury.Frontiers in pharmacology · 2025Review
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements.Journal of dietary supplements · 2025Review
- Comparative assessment of hepatoprotective properties of Artesunate and flavonoids fromMetabolism open · 2023Article
- Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats.BMC complementary medicine and therapies · 2023Article
- Sinapic acid ameliorates paracetamol-induced acute liver injury through targeting oxidative stress and inflammation.Molecular biology reports · 2022Article
- SIRT3 inhibitor 3-TYP exacerbates thioacetamide-induced hepatic injury in mice.Frontiers in physiology · 2022Article
- Protective Effect ofTheScientificWorldJournal · 2021Article
- Quercitrin Attenuates Acetaminophen-Induced Acute Liver Injury by Maintaining Mitochondrial Complex I Activity.Frontiers in pharmacology · 2021Article
- Acetaminophen Test Battery (ATB): A Comprehensive Method to Study Acetaminophen-Induced Acute Liver Injury.Gene expression · 2020Review
- Article
- Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.Journal of medicinal food · 2019Article
- Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis.Journal of ginseng research · 2019Article
- Effects of food restriction on the expression of genes related to acetaminophen-induced liver toxicity in rats.Journal of toxicologic pathology · 2018Article
- Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy.British journal of pharmacology · 2018Article
- Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis by modulating inflammation-related factors in rats.Journal of toxicologic pathology · 2018Article
- Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced byHeliyon · 2018Article
- Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers.Pharmaceutical biology · 2017Article
- Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil.Pharmaceutical biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Extracts from medicinal plants, many of which have been used for centuries, are increasingly tested in models of hepatotoxicity. One of the most popular models to evaluate the hepatoprotective potential of natural products is acetaminophen (APAP)-induced liver injury, although other hepatotoxicity models such as carbon tetrachloride, thioacetamide, ethanol and endotoxin are occasionally used. APAP overdose is a clinically relevant model of drug-induced liver injury. Critical mechanisms and signaling pathways, which trigger necrotic cell death and sterile inflammation, are discussed. Although there is increasing understanding of the pathophysiology of APAP-induced liver injury, the mechanism is complex and prone to misinterpretation, especially when unknown chemicals such as plant extracts are tested. This review discusses the fundamental aspects that need to be considered when using this model, such as selection of the animal species or in vitro system, timing and dose-responses of signaling events, metabolic activation and protein adduct formation, the role of lipid peroxidation and apoptotic versus necrotic cell death, and the impact of the ensuing sterile inflammatory response. The goal is to enable researchers to select the appropriate model and experimental conditions for testing of natural products that will yield clinically relevant results and allow valid interpretations of the pharmacological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.