SynthesisJournal of the American College of Cardiology2013
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.
Synthesis in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.Circulation. Genomic and precision medicine · 2019Pooled it
- The association of 9p21-3 locus with coronary atherosclerosis: a systematic review and meta-analysis.BMC medical genetics · 2014Pooled it
- Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis.Journal of the American College of Cardiology · 2014Pooled it
- Concordance of genetic determinants of acute coronary artery disease between European and Chinese populations.GigaScience · 2026Article
- Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors.BMC medical genomics · 2021Article
- A Functional Variant on 9p21.3 Related to Glioma Risk Affects Enhancer Activity and Modulates Expression of CDKN2B-AS1.Human mutation · 2021Article
- Genetic Risk Stratification: A Paradigm Shift in Prevention of Coronary Artery Disease.JACC. Basic to translational science · 2021Review
- Coronary Artery Disease: Association Study of 5 Loci with Angiographic Indices of Disease Severity.Disease markers · 2021Article
- Article
- Article
- Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes.Cardiovascular diabetology · 2019Observational
- Clinical application of chromosome 9p21.3 genotyping in patients with coronary artery disease.Experimental and therapeutic medicine · 2019Article
- 2018 George Lyman Duff Memorial Lecture: Genetics and Genomics of Coronary Artery Disease: A Decade of Progress.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Genome-Wide Association Studies of Hypertension and Several Other Cardiovascular Diseases.Pulse (Basel, Switzerland) · 2019Review
- Genome-wide association study of coronary artery calcification in asymptomatic Korean populations.PloS one · 2019Article
- Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.PloS one · 2019Article
- Review
- Cohort profile: the Emory Cardiovascular Biobank (EmCAB).BMJ open · 2017Article
- Article
- Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.The lancet. Diabetes & endocrinology · 2017Article
Corrections and comments
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Authors and funding
52 authors at 20 institutions in 7 countries.
Funding
Abstract
objectivesThis study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD.
backgroundChromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability.
methodsWe established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects.
resultsWe first confirmed an association between 9p21 and CAD with angiographically defined cases and control subjects (pooled odds ratio [OR]: 1.31, 95% confidence interval [CI]: 1.20 to 1.43). Among subjects with angiographic CAD (n = 20,987), random-effects model identified an association with multivessel CAD, compared with those with single-vessel disease (OR: 1.10, 95% CI: 1.04 to 1.17)/copy of risk allele). Genotypic models showed an OR of 1.15, 95% CI: 1.04 to 1.26 for heterozygous carrier and OR: 1.23, 95% CI: 1.08 to 1.39 for homozygous carrier. Finally, there was no significant association between 9p21 and prevalent MI when both cases (n = 17,791) and control subjects (n = 15,882) had underlying CAD (OR: 0.99, 95% CI: 0.95 to 1.03)/risk allele.
conclusionsThe 9p21 locus shows convincing association with greater burden of CAD but not with MI in the presence of underlying CAD. This adds further weight to the hypothesis that 9p21 locus primarily mediates an atherosclerotic phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.