ArticleCurrent biology : CB2013
Drosophila tracks carbon dioxide in flight.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
- Recurrent synapses between CO2-sensitive olfactory sensory neurons enable robust CO2 detection in Aedes aegypti mosquitoes.PLoS biology · 2026Article
- Recurrent connectivity supports carbon dioxide sensitivity inbioRxiv : the preprint server for biology · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Distinct neurogenetic mechanisms establish the same chemosensory valence state at different life stages in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2024Article
- Identification of candidate genes associated with host-seeking behavior in the parasitoid wasp Diachasmimorpha longicaudata.BMC genomics · 2024Article
- Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila.Nature communications · 2023Article
- Differential processing of a chemosensory cue across life stages sharing the same valence state inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- DehydratediScience · 2023Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- An internal expectation guidesScience advances · 2022Article
- Parallel encoding of COCurrent biology : CB · 2022Article
- Carbon dioxide and blood-feeding shift visual cue tracking during navigation inBiology letters · 2022Article
- Alternative oxidase (AOX) in the carnivorous pitcher plants of the genus Nepenthes: what is it good for?Annals of botany · 2022Article
- Review
- Review
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila.Current biology : CB · 2019Article
- Aedes aegypti Mosquitoes Use Their Legs to Sense DEET on Contact.Current biology : CB · 2019Article
- Avoidance response to CO2 in the lateral horn.PLoS biology · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Carbon dioxide (CO(2)) elicits an attractive host-seeking response from mosquitos yet is innately aversive to Drosophila melanogaster despite being a plentiful byproduct of attractive fermenting food sources. Prior studies used walking flies exclusively, yet adults track distant food sources on the wing. Here we show that a fly tethered within a magnetic field allowing free rotation about the yaw axis actively seeks a narrow CO(2) plume during flight. Genetic disruption of the canonical CO(2)-sensing olfactory neurons does not alter in-flight attraction to CO(2); however, antennal ablation and genetic disruption of the Ir64a acid sensor do. Surprisingly, mutation of the obligate olfactory coreceptor (Orco) does not abolish CO(2) aversion during walking yet eliminates CO(2) tracking in flight. The biogenic amine octopamine regulates critical physiological processes during flight, and blocking synaptic output from octopamine neurons inverts the valence assigned to CO(2) and elicits an aversive response in flight. Combined, our results suggest that a novel Orco-mediated olfactory pathway that gains sensitivity to CO(2) in flight via changes in octopamine levels, along with Ir64a, quickly switches the valence of a key environmental stimulus in a behavioral-state-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.