Evidence map›Paper›PMID 23352692›Full record

ReviewCurrent opinion in virology2013

Flaviviruses: braking the entering.

Theodore C Pierson, Margaret Kielian

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Dengue virus infection.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. West Nile virus unmasked: from gene variability to future challenges.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Reverse Genetics of Zika Virus Using a Bacterial Artificial Chromosome.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Theodore C PiersonViral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States. piersontc@mail.nih.gov
Margaret Kielian

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LIPKIN, W. IAN · 2003 to 2014
$100.8M
Molecular Analysis of Alphavirus Membrane Fusion ProteinR01AI075647 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KIELIAN, MARGARET · 2007 to 2023
$9.0M
MOLECULAR MECHANISMS OF ALPHAVIRUS ENTRY AND EXITR01GM057454 · NIGMS · YESHIVA UNIVERSITY · PI KIELIAN, MARGARET · 1999 to 2020
$7.2M
Mechanisms of Antibody-Mediated Neutralization of Flavivirus InfectionZIAAI000957 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PIERSON, THEODORE · 2009 to 2019
$7.1M
Intramural NIH HHS ZIA AI000957NIAID NIH HHS AI075647NIAID NIH HHS R01 AI075647NIAID NIH HHS U54 AI057158NIAID NIH HHS U54AI057158NIGMS NIH HHS GM057454NIGMS NIH HHS R01 GM057454
6 · The paper itself

Abstract

Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.

Indexed as

Virus InternalizationAnimalsAntiviral AgentsFlavivirusHumansModels, BiologicalModels, MolecularViral Envelope ProteinsAntiviral AgentsViral Envelope Proteins

Identifiers

PMID23352692
PMCPMC3601797

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.