ArticleCell reports2013
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed, 201 citations in OpenAlex.
- Article
- Genome-wide association study identifies significant SNPs for milk production and stature traits in Karan Fries cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Lgr5+ ductal cells of von Ebner's glands: Candidate stem cells for turnover of posterior tongue taste buds.PloS one · 2026Article
- Defining breast epithelial cell types in the single-cell era.Developmental cell · 2025Review
- CXCR4Nature communications · 2025Article
- 20 years of stemness: From stem cells to hypertranscription and back.Stem cell reports · 2025Review
- Functional and Biological Characterization of the LGR5Δ5 Splice Variant in HEK293T Cells.International journal of molecular sciences · 2024Article
- A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence.Immunity & ageing : I & A · 2023Article
- Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development.Stem cell reports · 2023Article
- Genetic heterogeneity of liver cancer stem cells.Anatomy & cell biology · 2023Article
- Gonadal Sex Differentiation and Ovarian Organogenesis along the Cortical-Medullary Axis in Mammals.International journal of molecular sciences · 2022Review
- The role of the Wnt signalling pathway in the energy metabolism of bone remodelling.Cell proliferation · 2022Review
- Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease.Experimental & molecular medicine · 2022Review
- Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis.Scientific reports · 2022Article
- SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency.Nature communications · 2022Article
- Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1.Cell reports · 2022Article
- Lgr5Theranostics · 2022Article
- The role of R-spondin proteins in cancer biology.Oncogene · 2021Review
- Dual recombinase action in the normal and neoplastic mammary gland epithelium.Scientific reports · 2021Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Mammary epithelial stem cells are vital to tissue expansion and remodeling during various phases of postnatal mammary development. Basal mammary epithelial cells are enriched in Wnt-responsive cells and can reconstitute cleared mammary fat pads upon transplantation into mice. Lgr5 is a Wnt-regulated target gene and was identified as a major stem cell marker in the small intestine, colon, stomach, and hair follicle, as well as in kidney nephrons. Here, we demonstrate the outstanding regenerative potential of a rare population of Lgr5-expressing (Lgr5(+)) mammary epithelial cells (MECs). We found that Lgr5(+) cells reside within the basal population, are superior to other basal cells in regenerating functional mammary glands (MGs), are exceptionally efficient in reconstituting MGs from single cells, and exhibit regenerative capacity in serial transplantations. Loss-of-function and depletion experiments of Lgr5(+) cells from transplanted MECs or from pubertal MGs revealed that these cells are not only sufficient but also necessary for postnatal mammary organogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.