ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2012
Natural gums as sustained release carriers: development of gastroretentive drug delivery system of ziprasidone HCl.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 40 citations in OpenAlex.
- Development of Novel Unfolding Film System of Itopride Hydrochloride Using Box-Behnken Design-A Gastro Retentive Approach.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Okra (Plants (Basel, Switzerland) · 2021Review
- Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review.Molecules (Basel, Switzerland) · 2021Review
- Pectin and Zinc Alginate: The Right Inner/Outer Polymer Combination for Core-Shell Drug Delivery Systems.Pharmaceutics · 2020Article
- Functional Components of Carob Fruit: Linking the Chemical and Biological Space.International journal of molecular sciences · 2016Review
- Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications.Marine drugs · 2016Review
- Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation.AAPS PharmSciTech · 2015Article
- Design, Development and Optimization of S (-) Atenolol Floating Sustained Release Matrix Tablets Using Surface Response Methodology.Indian journal of pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundObjective of this study is to show the potential use of natural gums in the development of drug delivery systems. Therefore in this work gastro retentive tablet formulations of ziprasidone HCl were developed using simplex lattice design considering concentration of okra gum, locust bean gum and HPMC K4M as independent variables. A response surface plot and multiple regression equations were used to evaluate the effect of independent variables on hardness, flag time, floating time and drug release for 1 h, 2 h, and 8 h and for 24 h. A checkpoint batch was also prepared by considering the constraints and desirability of optimized formulation to improve its in vitro performance. Significance of result was analyzed using ANOVA and p < 0.05 was considered statistically significant.
resultsFormulation chiefly contains locust bean gum found to be favorable for hardness and floatability but combined effect of three variables was responsible for the sustained release of drug. The in vitro drug release data of check point batch (F8) was found to be sustained well compared to the most satisfactory formulation (F7) of 7 runs. The 'n' value was found to be between 0.5 and 1 suggesting that release of drug follows anomalous (non-fickian) diffusion mechanism indicating both diffusion and erosion mechanism from these natural gums. Predicted results were almost similar to the observed experimental values indicating the accuracy of the design. In vivo floatability test indicated non adherence to the gastric mucosa and tablets remain buoyant for more than 24 h.
conclusionsStudy showed these eco-friendly natural gums can be considered as promising SR polymers.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.