Evidence map›Paper›PMID 23352218›Full record

ArticleImmunity2013

Inflammation makes T cells sensitive.

Elizabeth B Wilson, David G Brooks

Abstract readComment
In one paragraph

Article in Immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8International journal of molecular sciences · 2022
    Article
  2. Article
  3. Article
  4. T-cell exhaustion in allograft rejection and tolerance.Current opinion in organ transplantation · 2015
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Elizabeth B WilsonDepartment of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. lizbwilson@ucla.edu
David G Brooks

Funding

Mechanisms of Viral PersistenceR01AI085043 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BROOKS, DAVID G · 2010 to 2023
$4.5M
Immune Regulation of Viral Persistence and Clearance U01AI082975 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BROOKS, DAVID G · 2009 to 2013
$2.0M
NIAID NIH HHS R01 AI085043NIAID NIH HHS U01 AI082975
6 · The paper itself

Abstract

Inflammatory cytokines shape CD8(+) T cell responses. In this issue of Immunity, Richer et al. (2013) and Raue et al. (2013) demonstrate that inflammatory cytokines dynamically fine-tune antigen sensitivity of CD8(+) T cells to potently detect and better eliminate infected cells.

Identifiers

PMID23352218
PMCPMC3619688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.