ArticleChemistry & biology2013
A bacterial source for mollusk pyrone polyketides.
Article in Chemistry & biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
- Nocardiopsis oceanisediminis sp. nov., a Marine-Derived Actinobacterium Isolated from Sediment.Current microbiology · 2025Article
- Bacterial Diversity Associated with Terrestrial and Aquatic Snails.Microorganisms · 2024Review
- The Sobering Sting: Oleoyl Serotonin Is a NovelBiomedicines · 2024Article
- GenusMolecules (Basel, Switzerland) · 2022Review
- iChip-Inspired Isolation, Bioactivities and Dereplication ofMicroorganisms · 2022Article
- Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-DerivedMarine drugs · 2022Article
- GenusMarine drugs · 2022Review
- Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications.Marine drugs · 2022Review
- Synthetic study toward tridachiapyrone B.Beilstein journal of organic chemistry · 2022Article
- Composition of nutrient media and temperature of cultivation imposes effect on the content of secondary metabolites of3 Biotech · 2021Article
- Symbioses of Cyanobacteria in Marine Environments: Ecological Insights and Biotechnological Perspectives.Marine drugs · 2021Review
- Non-Peptidic Small Molecule Components from Cone Snail Venoms.Frontiers in pharmacology · 2021Review
- Article
- Isolation of Smenopyrone, a Bis-γ-Pyrone Polypropionate from the Caribbean SpongeMarine drugs · 2018Article
- Parallel lives of symbionts and hosts: chemical mutualism in marine animals.Natural product reports · 2018Review
- Evolutionary stability of antibiotic protection in a defensive symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.Applied and environmental microbiology · 2017Article
- Review
- Retrospective analysis of natural products provides insights for future discovery trends.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
In the oceans, secondary metabolites often protect otherwise poorly defended invertebrates, such as shell-less mollusks, from predation. The origins of these metabolites are largely unknown, but many of them are thought to be made by symbiotic bacteria. In contrast, mollusks with thick shells and toxic venoms are thought to lack these secondary metabolites because of reduced defensive needs. Here, we show that heavily defended cone snails also occasionally contain abundant secondary metabolites, γ-pyrones known as nocapyrones, which are synthesized by symbiotic bacteria. The bacteria, Nocardiopsis alba CR167, are related to widespread actinomycetes that we propose to be casual symbionts of invertebrates on land and in the sea. The natural roles of nocapyrones are unknown, but they are active in neurological assays, revealing that mollusks with external shells are an overlooked source of secondary metabolite diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.