ReviewTrends in genetics : TIG2013
Genetic determinants of voluntary exercise.
Review in Trends in genetics : TIG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Genetic Determinants of Leisure-Time Physical Activity in the Taiwanese Population: A Genome-Wide Association Study.Medicine and science in sports and exercise · 2025Article
- Maternal upbringing and selective breeding for voluntary exercise behavior modify patterns of DNA methylation and expression of genes in the mouse brain.Genes, brain, and behavior · 2023Article
- Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.Cell reports · 2023Article
- Article
- MiRNA-based "fitness score" to assess the individual response to diet, metabolism, and exercise.Journal of the International Society of Sports Nutrition · 2022Article
- Alleles associated with physical activity levels are estimated to be older than anatomically modern humans.PloS one · 2019Article
- Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults.Medicine and science in sports and exercise · 2018Article
- CC002/Unc females are mouse models of exercise-induced paradoxical fat response.Physiological reports · 2018Article
- Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse.Frontiers in immunology · 2018Article
- Awareness of treatment history in family and friends, and mental health care seeking propensity.Social psychiatry and psychiatric epidemiology · 2017Article
- Childhood temperament predictors of adolescent physical activity.BMC public health · 2017Article
- Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder.Neural plasticity · 2017Review
- Running from Disease: Molecular Mechanisms Associating Dopamine and Leptin Signaling in the Brain with Physical Inactivity, Obesity, and Type 2 Diabetes.Frontiers in endocrinology · 2017Review
- Long-term exercise in mice has sex-dependent benefits on body composition and metabolism during aging.Physiological reports · 2016Article
- Maternal exercise during pregnancy promotes physical activity in adult offspring.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors.Environmental science and pollution research international · 2016Article
- Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity.Journal of developmental origins of health and disease · 2015Article
- Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice.Journal of negative results in biomedicine · 2015Article
- Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle.Physiological genomics · 2014Article
- Wheel running in the wild.Proceedings. Biological sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Variation in voluntary exercise behavior is an important determinant of long-term human health. Increased physical activity is used as a preventative measure or therapeutic intervention for disease, and a sedentary lifestyle has generally been viewed as unhealthy. Predisposition to engage in voluntary activity is heritable and induces protective metabolic changes, but its complex genetic/genomic architecture has only recently begun to emerge. We first present a brief historical perspective and summary of the known benefits of voluntary exercise. Second, we describe human and mouse model studies using genomic and transcriptomic approaches to reveal the genetic architecture of exercise. Third, we discuss the merging of genomic information and physiological observations, revealing systems and networks that lead to a more complete mechanistic understanding of how exercise protects against disease pathogenesis. Finally, we explore potential regulation of physical activity through epigenetic mechanisms, including those that persist across multiple generations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.