ArticleMethods in enzymology2013
Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs.
Article in Methods in enzymology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
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- Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches.Molecules (Basel, Switzerland) · 2020Review
- TACI Isoforms Regulate Ligand Binding and Receptor Function.Frontiers in immunology · 2018Article
- A Guide to Approaching Regulatory Considerations for Lentiviral-Mediated Gene Therapies.Human gene therapy methods · 2017Review
- Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization.The Journal of biological chemistry · 2017Article
- The Conserved Arginine Cluster in the Insert of the Third Cytoplasmic Loop of the Long Form of the D₂ Dopamine Receptor (D2L-R) Acts as an Intracellular Retention Signal.International journal of molecular sciences · 2016Article
- Common and specific effects of TIE2 mutations causing venous malformations.Human molecular genetics · 2015Article
- Perspective on the role of the N-terminal tail of the α2C-adrenoceptor.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Expression and trafficking of functional G protein-coupled receptors are related, yet distinct, concepts.Naunyn-Schmiedeberg's archives of pharmacology · 2014Review
- Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.PLoS genetics · 2014Article
- The C-terminal half of the α2C-adrenoceptor determines the receptor's membrane expression level and drug selectivity.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Plasma membrane expression of G protein-coupled receptors (GPCRs) is a dynamic process balancing anterograde and retrograde trafficking. Multiple interrelated cellular processes determine the final level of cell surface expression, including endoplasmic reticulum (ER) export/retention, receptor internalization, recycling, and degradation. These processes are highly regulated to achieve specific localization to subcellular domains (e.g., dendrites or basolateral membranes) and to affect receptor signaling. Analysis of potential ER trafficking motifs within GPCRs requires careful consideration of intracellular dynamics, such as protein folding, ER export and retention, and glycosylation. This chapter presents an approach and methods for qualitative and quantitative assessment of these processes to aid in accurate identification of GPCR trafficking motifs, utilizing the analysis of a hydrophobic extracellular trafficking motif in α2C adrenergic receptors as a model system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.