Evidence map›Paper›PMID 23351732›Full record

ArticleMethods in enzymology2013

Trafficking of the follitropin receptor.

Alfredo Ulloa-Aguirre, James A Dias, George Bousfield, Ilpo Huhtaniemi, Eric Reiter

Open access · greenAbstract read
In one paragraph

Article in Methods in enzymology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Alfredo Ulloa-AguirreStudium Consortium for Research and Training in Reproductive Sciences (sCORTS), Tours, France. aulloaa@unam.mx
James A Dias
George Bousfield
Ilpo Huhtaniemi
Eric Reiter
Clinical Research Consortium · USPhysiologie de la Reproduction et des Comportements · FR

Funding

The Aging Pituitary/Gonadal AxisP01AG029531 · NIA · WICHITA STATE UNIVERSITY · PI GEORGE R BOUSFIELD · 2009 to 2026
$25.9M
STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORSR01HD018407 · NICHD · WADSWORTH CENTER · PI A, DIAS JAMES · 1985 to 2010
$2.4M
NIA NIH HHS AG029531NIA NIH HHS P01 AG029531NICHD NIH HHS HD18407NICHD NIH HHS R01 HD018407Wellcome Trust
6 · The paper itself

Abstract

The follitropin or follicle-stimulating hormone receptor (FSHR) belongs to a highly conserved subfamily of the G protein-coupled receptor (GPCR) superfamily and is mainly expressed in specific cells in the gonads. As any other GPCR, the newly synthesized FSHR has to be correctly folded and processed in order to traffic to the cell surface plasma membrane and interact with its cognate ligand. In this chapter, we describe in detail the conditions and procedures used to study outward trafficking of the FSHR from the endoplasmic reticulum to the plasma membrane. We also describe some methods to analyze phosphorylation, β-arrestin recruitment, internalization, and recycling of this particular receptor, which have proved useful in our hands for dissecting its downward trafficking and fate following agonist stimulation.

Indexed as

AnimalsArrestinsbeta-ArrestinsBlotting, WesternElectrophoresis, Polyacrylamide GelFluorescence Resonance Energy TransferFollicle Stimulating HormoneHumansImmunoprecipitationMutationPhosphorylationProtein MultimerizationProtein TransportReceptors, FSHArrestinsbeta-ArrestinsFollicle Stimulating HormoneReceptors, FSH

Identifiers

PMID23351732
PMCPMC4503599
OpenAlexW257540041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.