ArticleNanoscale research letters2013
Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies.
Article in Nanoscale research letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Rethinking Meta-Analysis: Applications for Air Pollution Data and Beyond.Risk analysis : an official publication of the Society for Risk Analysis · 2015Pooled it
- Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort.BMJ (Clinical research ed.) · 2018Trial
- Titanium Dioxide Nanoparticles Aggravated the Developmental Neurotoxicity of Ammonia Nitrogen on Zebrafish Embryos.Toxics · 2025Article
- Recent Advances in Machine Learning Models for Predicting Toxicity of Inorganic Nanoparticles.Chem & bio engineering · 2025Review
- How TiOInternational journal of nanomedicine · 2025Review
- Titanium dioxide nanoparticles Disrupt ultrastructure and function of Rat thyroid tissue via oxidative stress.Heliyon · 2024Article
- Ultra-processed food consumption and risk of chronic respiratory diseases mortality among adults: evidence from a prospective cohort study.European journal of nutrition · 2024Article
- Inactivation of mammalian spermatozoa on the exposure of TiOJournal of analytical science and technology · 2023Article
- Food processing groups and colorectal cancer risk in Morocco: evidence from a nationally representative case-control study.European journal of nutrition · 2022Article
- A comprehensive review on electrospun nanohybrid membranes for wastewater treatment.Beilstein journal of nanotechnology · 2022Review
- Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment.Nanomaterials (Basel, Switzerland) · 2021Review
- Cardiac and testicular alterations induced by acute exposure to titanium dioxide nanoparticles: Histopathological study.IET nanobiotechnology · 2021Article
- Titanium dioxide nanoparticles induced the apoptosis of RAW264.7 macrophages through miR-29b-3p/NFAT5 pathway.Environmental science and pollution research international · 2020Article
- Genotoxicity of TiONanomaterials (Basel, Switzerland) · 2020Article
- TiOFood science and biotechnology · 2019Article
- Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin.Environmental science and pollution research international · 2019Article
- Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiOToxicology research · 2019Article
- Article
- Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France.JAMA internal medicine · 2019Observational
- Novel Cancer Treatment Using Targeted Delivery of Short-Lived Radiologically Activated Nanoparticles.Journal of health science (El Monte) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paper is aimed to investigate the toxicity of nano-TiO2 and its potential harmful impact on human health using meta-analysis of in vitro and short-time animal studies. Data were retrieved according to included and excluded criteria from 1994 to 2011. The combined toxic effects of nano-TiO2 were calculated by the different endpoints by cell and animal models. From analysis of the experimental studies, more than 50% showed positive statistical significance except the apoptosis group, and the cytotoxicity was in a dose-dependent but was not clear in size-dependent manner. Nano-TiO2 was detained in several important organs including the liver, spleen, kidney, and brain after entering the blood through different exposure routes, but the coefficient of the target organs was altered slightly from animal models. It is possible that nano-TiO2 can induce cell damage related to exposure size and dose. Further studies will be needed to demonstrate that nanoparticles have toxic effects on human body, especially in epidemiological studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.